Navigation Links
Scientists Discover Gene Regulator That Helps Hearts Through Exercise
Date:6/2/2011

CLAREMONT, Calif., June 2, 2011 /PRNewswire/ -- Providing a medical explanation for why exercise is good for the heart, a team of scientists from Brazil pursuing a study that started in Dr. Ian Phillips' lab at Keck Graduate Institute (KGI) has discovered a new gene regulator called MicroRNA 29 that keeps hearts healthy even under intense exercise.

"Now, we're beginning to get to the molecular basis of why exercise is good for you," said Phillips, KGI's Norris Professor of Applied Life Sciences. "It's well known that athletes get large hearts and they remain healthy while people with large hearts, who are not athletes, are in big trouble. But we've never known before why they were different."

Dr. Edilamar de Oliveira, a biochemistry professor in the Physical Education School at the University of Sao Paulo, worked with Phillips while doing postdoctoral studies at KGI from 2007-09. Applying what she learned about MicroRNAs to her research on physical training and cardiac hypertrophy after returning to Brazil, de Oliveira found MicroRNAs act as brakes on specific genes, inhibiting what proteins those genes produce.

De Oliveira and her team found that rats, who trained like athletes (two and three times a day) on a 10-week regimen involving swimming with 5% weights overload, expressed much higher levels of MicroRNA 29 than sedentary rats. And, even though the athletic rats' hearts were enlarged, they did not develop an excess of collagen fibers, which interferes with the heart's ability to pump effectively. (Bad hearts are full of collagen and good hearts have very little collagen.)

Results of the study were published in the latest issue of the journal Physiological Genomics. The first author is Ursula Soci, one of De Oliveira's PhD students.

"The paper reports the discovery of the regulator of the genes that decide whether the heart is going to be healthy or unhealthy," Phillips said.

The discovery has broad implications for individuals with heart disease and congestive heart failure.

Because MicroRNA 29 stops collagen genes from building up in the heart, injections of it might have therapeutic value, according to Phillips.

De Oliveira has received a grant for the next step in their research, which will involve injecting hypertensive rats with MicroRNA 29 to see if the gene inhibiter can prevent the development of large, unhealthy hearts because of hypertension.

KGI BACKGROUND

Educating the future leaders of the bioscience industry, Keck Graduate Institute (KGI) offers an interdisciplinary graduate education through its Master of Bioscience (MBS), Postdoctoral Professional Masters in Bioscience Management (PPM), Postbaccalaureate Premedical Certificate (PPC), PhD and other academic programs. Using team-based learning and real-world projects, KGI's innovative curriculum seamlessly combines applied life sciences, bioengineering, bioethics and business management. KGI also has a robust research program concentrating on the translation of basic discoveries in the life sciences into applications that can benefit society.  KGI is a member of The Claremont Colleges, located in Claremont, California.

Keck Graduate Institute of Applied Life Sciences is dedicated to education and research aimed at translating into practice, for the benefit of society, the power and potential of the life sciences.


'/>"/>
SOURCE Keck Graduate Institute
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... September 19, 2017 , ... A best-selling author and an ... “Grit” author Angela Duckworth and her team at Character Lab have joined Philadelphia’s ... international law firm with decades of experience supporting high-growth companies in the technology ...
(Date:9/19/2017)... ... September 19, 2017 , ... One of the biggest ... eliminated, said Lyle Probst, President, CEO and Founder of ExcitePCR ™. ... pathogen detection solutions, Probst said, “Sample preparation takes place inside our FireflyDX systems, ...
(Date:9/19/2017)... , ... September 19, 2017 , ... ... today announced a partnership with Cytena GmbH to launch the CloneSelect™ Single-Cell Printer™ ... image analysis to isolate single cells and provide visual documentation of monoclonality for ...
(Date:9/18/2017)... ... September 18, 2017 , ... ... to produce biochar, briquettes, and torrefied wood is the topic of a ... To characterize the potential economic viability of transportable biomass conversion facilities for producing ...
Breaking Biology Technology:
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
Breaking Biology News(10 mins):