Navigation Links
Scientists Discover Gene Regulator That Helps Hearts Through Exercise
Date:6/2/2011

CLAREMONT, Calif., June 2, 2011 /PRNewswire/ -- Providing a medical explanation for why exercise is good for the heart, a team of scientists from Brazil pursuing a study that started in Dr. Ian Phillips' lab at Keck Graduate Institute (KGI) has discovered a new gene regulator called MicroRNA 29 that keeps hearts healthy even under intense exercise.

"Now, we're beginning to get to the molecular basis of why exercise is good for you," said Phillips, KGI's Norris Professor of Applied Life Sciences. "It's well known that athletes get large hearts and they remain healthy while people with large hearts, who are not athletes, are in big trouble. But we've never known before why they were different."

Dr. Edilamar de Oliveira, a biochemistry professor in the Physical Education School at the University of Sao Paulo, worked with Phillips while doing postdoctoral studies at KGI from 2007-09. Applying what she learned about MicroRNAs to her research on physical training and cardiac hypertrophy after returning to Brazil, de Oliveira found MicroRNAs act as brakes on specific genes, inhibiting what proteins those genes produce.

De Oliveira and her team found that rats, who trained like athletes (two and three times a day) on a 10-week regimen involving swimming with 5% weights overload, expressed much higher levels of MicroRNA 29 than sedentary rats. And, even though the athletic rats' hearts were enlarged, they did not develop an excess of collagen fibers, which interferes with the heart's ability to pump effectively. (Bad hearts are full of collagen and good hearts have very little collagen.)

Results of the study were published in the latest issue of the journal Physiological Genomics. The first author is Ursula Soci, one of De Oliveira's PhD students.

"The paper reports the discovery of the regulator of the genes that decide whether the heart is going to be healthy or unhealthy," Phillips said.

The discovery has broad implicat
'/>"/>

SOURCE Keck Graduate Institute
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 2014 Last year, Formedix ... leading global provider of data management solutions for clinical ... leading-edge system for electronic data capture (EDC) and clinical ... and study execution tools added TrialMaster to its Transform ... version of Transform for TrialMaster, is being released this ...
(Date:7/23/2014)... , 23 de julio de 2014 ... la Compañía) ha anunciado hoy una asociación con ... (ABIA o el Instituto), para el propósito ... dispositivo de terapia de señal bioeléctrica (el E-QURE ... El Instituto, que tiene una importante experiencia en ...
(Date:7/23/2014)... TEL AVIV, Israel , July 23, 2014 ... Ltd ., a portfolio company of Trendlines ... with one of Israel,s ... (Logo: http://photos.prnewswire.com/prnh/20140121/666259-a) , Valentis,s technology combines ... from plant pulp waste, with additional nanoparticles to ...
(Date:7/23/2014)... - BioAmber Inc. (NYSE: BIOA ), ... that the underwriters of its common stock offering ... additional 420,000 shares of common stock at the ... underwriting discounts and commissions, in connection with its ... of common stock, bringing the expected net proceeds ...
Breaking Biology Technology:Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 4ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 5ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 6Valentis Nanotech Signs MOU to Integrate Technology in Thermoplastics Production 2BioAmber announces exercise in full of underwriters' option in connection with previously priced follow-on offering 2BioAmber announces exercise in full of underwriters' option in connection with previously priced follow-on offering 3
... Quarter ... Salesforce ... Insulet Corporation,(Nasdaq: PODD ), a leader in wearable insulin ... for,the first quarter ended March 31, 2008., First quarter 2008 ...
... 13 Hospira, Inc.,(NYSE: HSP ), a ... that Barbara L. Bowles, CFA, has been elected ... investment,management and finance expertise from leadership positions held ... advisory,firms. The addition of Bowles expands Hospira,s board ...
... Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , TSX: ANP), ... announced the appointment of Dr. Hank,McKinnell to its ... former Chief Executive Officer and former Chairman,of the ... currently Chairman of the,Accordia Global Health Foundation, an ...
Cached Biology Technology:Insulet Reports First Quarter 2008 Results 2Insulet Reports First Quarter 2008 Results 3Insulet Reports First Quarter 2008 Results 4Insulet Reports First Quarter 2008 Results 5Insulet Reports First Quarter 2008 Results 6Insulet Reports First Quarter 2008 Results 7Hospira Expands Board of Directors 2Angiotech appoints Hank McKinnell to its Board of Directors 2
(Date:7/23/2014)... State University shows that urban "heat islands" are slowly ... factor is that researchers have found warmer temperatures increase ... insect a significant tree pest by 300 ... adult gloomy scales on urban trees. , "We,d been ... scale in cities, and now we know why," says ...
(Date:7/23/2014)... lab experiments using tissue samples cultured from cystic fibrosis ... the UNC Marsico Lung Institute have shown that a ... of another CF drug. , The finding, published today ... how a mutant CFTR protein becomes unstable and loses ... of the two drugs. The research offers several insights ...
(Date:7/23/2014)... drought that has the entire country in its grip is ... also be responsible for the proliferation of a heat-loving amoeba ... and hot springs, which the drought has made warmer than ... of an infection caused by this parasite after swimming in ... nose of an individual and travels to the brain. Nose ...
Breaking Biology News(10 mins):Urban heat boosts some pest populations 200-fold, killing red maples 2Urban heat boosts some pest populations 200-fold, killing red maples 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 4Diseases of another kind 2
... Penn State researchers have found that native pollinators, ... same viral diseases as honey bees and that these ... on December 22nd in PLoS ONE, an online open-access ... medical research. This multi-institutional study provides new insights ...
... Researchers at the University of Minnesota have discovered ... antiviral protein called APOBEC3F. The results suggest that a ... effective antiviral agent and that shielding of a common ... outcome. This discovery highlights the potential for a ...
... can scientists learn from watching a group of people ... new friends? Quite a lot, says University of Melbourne, ... of group in a fatigue management study he and ... the Acoustical Society of America. Their report shows ...
Cached Biology News:Movement and threat of RNA viruses widespread in pollinator community 2University of Minnesota discovery suggests a new way to prevent HIV from infecting human cells 2Measuring fatigue through the voice 2
... is a fully automated microplate based ... labs in academia and industry. The ... Fluorescence Intensity including FRET ... including DELFIATM High-Performance Luminescence ...
... CYCLES. An assay kit designed to detect ... PARP is an enzyme implicated in DNA ... is cleaved by caspase-3. Cleavage of PARP ... kDa is a hallmark of apoptosis. Each ...
... operate as a Voltage Clamp, as a Current ... electrophysiology research applications. Performance in any one mode ... • This amazing instrument is ... capabilities of Digital Signal Processing (DSP) integrated circuit ...
... comes with a shutter (controlled via a TTL ... The DH-2000 Deuterium Tungsten Halogen Light ... tungsten halogen light sources in a single optical ... stable output from 215-200 nm. In addition, deep-UV ...
Biology Products: