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Scientist chronicle nanoparticles' journey from the lungs into the body
Date:11/8/2010

ith "zwitterionic" characteristics (equal positive and negative charge) traveled to the draining lymph nodes within just a few minutes, subsequently being cleared by the kidneys into urine.

"These new findings can be applied to design and optimize particles for drug delivery by inhalation therapy," notes Tsuda. "This research also guides us in the assessment of the health effects of various particulate pollutants, as the data suggest the importance of distinguishing specific subclasses of particles [based on surface chemistry and size] that can rapidly cross the alveolar epithelium and may disseminate in the body."

Adds Frangioni, "This study complements our earlier work in which we defined the characteristics of nanoparticles that regulate efficient clearance from the body. With these new findings, which define the characteristics that regulate uptake into the body, we've now described a complete 'cycle' of nanoparticle trafficking --from the environment, through the lungs, into the body, then out of the kidneys in urine and back to the environment."


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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