Navigation Links
Scientific breakthrough in genetic studies of animal domestication
Date:3/10/2010

years ago".

A selective sweep takes place when a favorable mutation becomes fixed in a population. This happens in all species during the course of evolution and it happens in domestic animals as a consequence of human-driven selection for favored traits. One of the most interesting findings in this study was a striking selective sweep at the TSHR gene that codes for the thyroid-stimulating hormone receptor. In vertebrates, this protein has a key role in metabolic regulation but also in determining the timing of reproduction as a response to changes in day length, a trait that is strictly controlled in most wild animals but which is drastically altered in domestic chickens that can reproduce all year around.

"Our discovery that every domestic chicken that we have studied representing populations from Sweden to China carry a mutant form of the TSHR protein strongly suggests that this genetic change was an important step in the evolution of the domestic chicken", says Leif Andersson.

Another very convincing selective sweep was observed in broiler chickens and involved the TBC1D1 gene, a gene that has previously been associated with obesity in humans and the TBC1D1 protein is involved in the regulation of glucose uptake in muscle cells.

"Our study shows that billions of broiler chickens worldwide carry a mutant form of the TBC1D1 gene and we are now very eager to identify the causative mutation at this locus and to reveal the molecular mechanism by which it impacts growth", says Carl-Johan Rubin who was responsible for the bioinformatic analysis of selective sweeps.

The study is a breakthrough as regards genetic studies of domestic animals.

"Our study has direct implications for animal breeding and enhances the importance of the domestic chicken as a model organism for biomedical research since we can so effectively reveal genes associated with changes in phenotypic traits", concludes Leif Andersson.


'/>"/>

Contact: Leif Andersson
Leif.Andersson@imbim.uu.se
46-705-144-904
Uppsala University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Orameds Chief Scientific Officer, Miriam Kidron, Ph.D., Chosen to Lecture at the Third International Conference on Advanced Technologies and Treatments for Diabetes in Basel, Switzerland
2. Japan Science and Technology Agency (JST) Selects Scopus Custom Data for Citation Linkage Analysis Between Scientific Articles and Patents
3. Joint BioEnergy Institute Selects Surety's AbsoluteProof to Protect the Integrity and Legally Defend the Authenticity of its Scientific Intellectual Property
4. Boston Scientific Announces Completion of $2 Billion Senior Notes Offering
5. Science Education Experts Discuss Solutions for Global Competitiveness at Scientific American Forum
6. Vivakor Announces Additions to Board of Directors and Scientific Advisory Board
7. Advanced Cell Technologys Chief Scientific Officer, Robert Lanza, Opening Plenary Speaker at the 3rd International Conference on Cell Therapy
8. WaferGen Names Christopher Sears, Ph.D., Architect of High-Value Molecular Diagnostics and Computational Biology Platforms, to Companys Scientific Advisory Board
9. Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health
10. Cytochroma Appoints Dr. John Cunningham to its Scientific Advisory Board
11. DOE to Explore Scientific Cloud Computing at Argonne, Lawrence Berkeley National Laboratories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... , July 25, 2014  Galmed Pharmaceuticals Ltd. ... company focused on the development and commercialization of a ... and cholesterol gallstones, today announced financial results for the ... 2014 Financial Summary: , Reported cash and cash ... with $137,000 at December 31, 2013.  , Reported ...
(Date:7/25/2014)... , July 25, 2014 Sinovac Biotech Ltd. (Nasdaq: ... in China , today announced that it ... ended June 30, 2014, after market close on Thursday, August ... prior to the market opening on Friday, August 15, 2014, ... p.m. China Standard Time) to review the Company,s financial results ...
(Date:7/24/2014)... July 24, 2014 Gain recognition ... Supply Chain of the biotech industry. Nominations are ... Awards, brought to you by the Bio ... of supply chain management professionals for the past ... stakeholders of the Biotech industry – Manufacturers, Service ...
(Date:7/24/2014)... 2014  ECC West Africa, LLC (ECC) signed a ... University College Hospital (UCH) Ibadan Board of Management for ... design, construct, and operate and maintain a new, state-of-the-art ... Under the first of the 4-phase project, ECC will ... applications. UCH Ibadan intends to finance and develop the ...
Breaking Biology Technology:Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2
... Researchers at Rensselaer Polytechnic Institute have developed ... a key step for advancing integrated 3-D chip ... or anneal, at about 300 degrees Celsius. This ... ideal for use in heat-sensitive nanoelectronics, particularly for ...
... H. Robert Superko, MD, principal investigator in the landmark ... at Saint Joseph,s Hospital in Atlanta, released preliminary findings ... risk of suffering sudden death or other significant cardiac ... hundred percent increased risk for cardiac disease as compared ...
... Cardio-diagnostic company adds new apoAI measurement and apoB/apoAI ratio ... Ala., March 17 /PRNewswire/ -- ... VAP(R) Cholesterol Test in booth #1263 at ACC.09, the ... Exposition. The annual meeting takes place March 29-31, 2009, ...
Cached Biology Technology:Slimmer, stickier nanorods give boost to 3-D computer chips 2Heart Disease: An Epidemic For Firefighters 2Heart Disease: An Epidemic For Firefighters 3Atherotech to Exhibit the VAP(R) Cholesterol Test at ACC.09 in Orlando 2Atherotech to Exhibit the VAP(R) Cholesterol Test at ACC.09 in Orlando 3
(Date:7/24/2014)... new study has identified two factors that characterize ... the production of highly qualified physics teachers. Specifically, ... champion physics teacher education in combination with institutional ... remain viable. Science, Technology, Engineering and Math (STEM) ... the study points the way for institutions seeking ...
(Date:7/24/2014)... biodiversity, the product of 3.5 billion years of evolutionary ... of life. But it may be reaching a tipping ... and analysis of data published in Science , ... and decline of animals is contributing to what appears ... mass biological extinction event. , Since 1500, more than ...
(Date:7/24/2014)... its own microbial terroir, meaning the microbial populations found ... the product, creating the final flavor according to research ... and Environmental Microbiology . This is the first time ... brewery. , Many sake makers inoculate with both ... of the University of California, Davis, but he and ...
Breaking Biology News(10 mins):Creating sustainable STEM teacher preparation programs 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3The microbes make the sake brewery 2
... Michigan have shown that their new metabolic imaging instrument can ... a device would be vision-saving because many severe eye diseases ... diminish vision. The testing is noninvasive and takes less than ... recent study, two researchers from the U-M Kellogg Eye Center ...
... memory works is emerging from a newfound ability to ... changes in the inner workings of its neurons. Researchers, ... National Institute of Mental Health (NIMH), have developed a ... a specific memory in genetically-engineered mice. "Remarkably, this ...
... threatening the staple diet of millions in Africa ... today, bringing together plant experts from Leeds and ... Urwin from the University of Leeds Faculty of ... 7 million Sustainable Agriculture Research for International Development ...
Cached Biology News:'Fluorescent' cells give early warning for eye disease 2Genetic tags reveal secrets of memories' staying power in mice 2Genetic tags reveal secrets of memories' staying power in mice 3Purging the plantain pests in Africa 2
Ms anti-Cyclophilin D...
... Intended to qualitatively detect ... formalin-fixed, paraffin-embedded (FFPE) tissue ... and cell preparations, using ... (CISH). Fluorescent In Situ ...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient...
Biology Products: