Navigation Links
Science study shows 'promiscuous' enzymes still prevalent in metabolism
Date:8/30/2012

Open an undergraduate biochemistry textbook and you will learn that enzymes are highly efficient and specific in catalyzing chemical reactions in living organisms, and that they evolved to this state from their sloppy and promiscuous ancestors to allow cells to grow more efficiently. This fundamental paradigm is being challenged in a new study by bioengineers at the University of California, San Diego, who reported in the journal Science what a few enzymologists have suspected for years: many enzymes are still pretty sloppy and promiscuous, catalyzing multiple chemical reactions in living cells, for reasons that were previously not well understood.

In this study, the research team, led by Bernhard Palsson, Galetti Professor of Bioengineering at the UC San Diego Jacobs School of Engineering, brought together decades of work on the behavior of individual enzymes to produce a genome-scale model of E. coli metabolism and report that at least 37 percent of its enzymes catalyze multiple metabolic reactions that occur in an actively growing cell.

Weve been able to stitch all of the enzymes together into one giant model, giving us a holistic view of what has been driving the evolution of enzymes and found that it isnt quite what weve thought it to be, said Palsson.

When organisms evolve, it is the genes or proteins that change. Therefore, gene and protein evolution has classically been studied one gene at a time. However in this work, Palsson and his colleagues, introduce an important paradigm shift by demonstrating that the evolution of individual proteins and enzymes is influenced by the function of all of the other enzymes in an organism, and how they all work together to support the growth rate of the cell.

Using a whole-cell model of metabolism, the research team found that the more essential an enzyme is to the growth of the cell, the more efficient it needs to be; meanwhile, enzymes that only weakly contribute to cell growth can
'/>"/>

Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Garage Start-ups Now Possible in Life Sciences Industry
2. Fitzsimons Redevelopment Authority Rolls Out First Phase of Strategic Refocus With Appointment of Four Key Leaders in The Bioscience Industry to Its Board of Directors
3. Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer
4. Kansas Bioscience Authority Announces FY11 Outcomes of $207 Million
5. A New Mechanism for Tau Protein Pathology in Alzheimers Disease was Presented by Oligomerix, Inc. at the Society for Neuroscience Annual Meeting
6. BioSpace Spotlights Northwests Life Science Community
7. CNR Rao wins 2011 Ernesto Illy Trieste Science Prize
8. DiaTech Life Sciences Announces Medical Advisory Board
9. Health Diagnostic Laboratory, Inc. Provides Largest Corporate Gift in Science Museum of Virginias History
10. The Law Firm of Levi & Korsinsky, LLP Launches an Investigation Into Possible Securities Laws Violations by Pacific Biosciences of California, Inc.
11. Leaders in Science Join Upcoming Celebration of the 100th Anniversary of the Oldest Science Foundation in America
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Science study shows 'promiscuous' enzymes still prevalent in metabolism
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. – ... Warrington, Pa. , Details: The Hepatitis B Foundation, ... cure for hepatitis B and improving the quality of life ... on Friday, April 11 at Warrington Country Club in Warrington, ...
(Date:1/14/2014)... January 14, 2014 EquitiesIQ, a leading ... (OTCQB: ALQA). Alliqua is an emerging biomedical company acquiring, ... wound care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... a seasoned management team and Board, which launched the ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation ... developing and commercializing innovative therapies addressing major unmet ... it received the Notice of Allowance from the ... unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment ...
(Date:1/14/2014)... Rochester, NY (PRWEB) January 14, 2014 During ... is now known as “The Doctor’s Plague.” In this time ... their hands. This led, at times, to the death of ... staff today don’t know that they may be unwittingly transmitting ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... HCTL ), today announced unaudited results for the,second quarter ... for the first six months of 2007 were $7.75 million, ... The gross profit for the,first half of the year was ... The net loss for such period was $(319) thousand, versus ...
... 16 Cepheid (Nasdaq:,CPHD) today announced that it ... Northrop Grumman for the purchase of up to ... associated materials. The,anthrax test is currently used in ... Service (USPS) mail processing centers,nationwide. The agreement covers ...
... Topic of Drug Repurposing and ... Indian Clinical Trial Strategy, ... biopharmaceutical company, announced today,that Chief Executive Officer, John Maki, and ... 234th American Chemical,Society National Meeting on Sunday, August 19, 2007. ...
Cached Biology Technology:Healthcare Technologies Reports Loss for 2007 Second Quarter & Six Months Results 2Healthcare Technologies Reports Loss for 2007 Second Quarter & Six Months Results 3Cepheid Enters Into Five-Year Agreement With Northrop Grumman for the Purchase of Anthrax Test Cartridges for Use in United States Postal Service Biohazard Detection Systems 2Cepheid Enters Into Five-Year Agreement With Northrop Grumman for the Purchase of Anthrax Test Cartridges for Use in United States Postal Service Biohazard Detection Systems 3Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA 2Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA 3
(Date:4/23/2014)... found evidence of an interaction between prenatal smoking ... in children, especially in girls. , "The interesting ... prenatal smoking will have behavioral problems. Some ... Assistant Professor at Sam Houston State University, College ... study. "One possible explanation for this is ...
(Date:4/23/2014)... yesterday, Argentina joins the European Molecular Biology Laboratory ... strengthens the ties between the European and Latin ... access to EMBL,s world-class facilities and programs, and ... inception, fostering excellent life science research and promoting ... EMBL,s mission," says EMBL Director General Iain Mattaj ...
(Date:4/23/2014)... coined term for novels and films which focus on the ... shows how these fictions serve as a mental laboratory that ... and imagine other living conditions. , "Global warming is ... it is also a cultural phenomenon in which meaning is ... we see. And there are so many of them now ...
Breaking Biology News(10 mins):Genetics risk, prenatal smoking may predict behavioral problems 2Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3
... Life Sciences Discovery Fund (LSDF) today announced its ... will receive life sciences program grants totaling more ... will focus on advancing vaccine development, improving the ... of mental health and substance abuse services in ...
... all a protein needs to do is give quick squeezes ... from The University of Arizona in Tucson. Scientists ... readings of the information coded in the DNA,s sequence. ... called direct readout, can effectively pinpoint sites on DNA using ...
... . , Montreal, December 16, 2008 ... Stephen Michnick is helping the scientific community uncover the ... biochemistry professor and Canada Research Chair in Integrative Genomics, ... him to examine how proteins interact within cells. ...
Cached Biology News:Life Sciences Discovery Fund awards health research program grants 2Life Sciences Discovery Fund awards health research program grants 3Life Sciences Discovery Fund awards health research program grants 4Life Sciences Discovery Fund awards health research program grants 5Just a little squeeze lets proteins assess DNA 2Just a little squeeze lets proteins assess DNA 3Call Stephen Michnick a gene grammarian 2
Goat polyclonal to p27 KIP 1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-KRPATDDS STQNK, corresponding to Internal sequence amino acids 153-165 of Human p27 KIP 1 ...
Request Info...
Myt 1 (N-17)...
... are functionally defined by their capacity to ... into multiple specialized progenitor cells, which can ... Neural stem cells (NSCs) are capable of ... neurons and oligodendrocytes. During the isolation and ...
Biology Products: