Navigation Links
Savient's Pegloticase Data in Treatment-Failure Gout Patients Presented at 72nd Annual Meeting of the American College of Rheumatology Conference
Date:10/27/2008

t. With continued pegloticase therapy beyond 6

months in the GOUT 3 study, the proportion of patients demonstrating a

Complete Response for tophus resolution increased over time in both the

every 2 weeks and every 4 weeks groups. While other clinical

assessments also showed clinical improvements, such as a partial tophus

response, it is only the tophus Complete Response that was pre-

specified as a clinical criterion by which to measure success. It is

very encouraging that many patients, who had a tophus partial response

in the first six months of treatment, developed a Complete Response

over a longer treatment period in GOUT 3.

-- Gout Flares: The GOUT 1 and GOUT 2 pivotal studies assessed the affect

of pegloticase treatment on both an efficacy and safety secondary

endpoints in gout flares. As with all urate-lowering therapies, the

frequency of flares increased upon initiation of pegloticase treatment

as expected. The treatment-failure gout patients in the Phase 3

program had a high frequency of gout flares prior to study entry, as

shown by the approximately 1.7 flares per the initial 3-month period

for the placebo group. In the pooled analyses, pegloticase-induced

increase in gout flares occurred in both treatment groups during Months

1-3 to a frequency of about 2.3 and 2.7 respectively, whereas the

placebo group showed no change in flare frequency during the same 3-

month period.

New data presented at ACR demonstrates that in Months 4-6 patients

administered pegloticase every 2 weeks had a statistically

significant lower flare incidence and frequency compared to placebo

patients in the pooled analysis. Additionally, in Months 4-6, the

pegloticase every 4 weeks group had a frequency of gout flares similar

to placebo indi
'/>"/>

SOURCE Savient Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology technology :

1. One-Year Data Show Golimumab Improved Signs and Symptoms In Patients with Psoriatic Arthritis In Phase 3 Study
2. Intensive Lifestyle Intervention Program for Overweight or Obese Patients with Nonalcoholic Steatohepatitis Reduces Weight and Improves Overall Liver Health
3. UKs NICE Recommends Spinal Cord Stimulation for Patients with Chronic Neuropathic Pain
4. Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients
5. AdvanDxs PNA FISH(TM) Test Shown to Reduce Mortality by 42% for Patients With Hospital-Acquired Enterococcus faecium Bloodstream Infections
6. Poniard Announces Positive Incremental Efficacy and Safety Data from Phase 2 Picoplatin Trial in Patients With Metastatic Colorectal Cancer
7. Peregrine Pharmaceuticals Reports Progress in Its Phase II Trial of Bavituximab Plus Docetaxel in Patients With Advanced Breast Cancer
8. Novel Mass Spectrometry-based Assay Reveals Degradation and Low Levels of Bioactive B-type Natriuretic Peptide (BNP) in Patients with Heart Failure
9. Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure
10. DaVita Treats Thousands of Dialysis Patients in Wake of Hurricane Ike
11. Fujitsu PalmSecure and HT Systems PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... 2014 Best Sanitizers, Inc., a leader ... processing industry, is asking industry professionals to prepare for ... the E2 soap they’re currently using to the Best ... Hand hygiene is critical to fighting cross-contamination and ... Six key criteria are identified to evaluate the effectiveness ...
(Date:8/28/2014)... August 28, 2014 Best Sanitizers, Inc., ... an alcohol-based hand sanitizer, asks food processors and food ... the hand sanitizer they’re currently using to Best Sanitizers’ ... hygiene is critical to fighting cross-contamination and the spread ... Sanitizers believes there are key criteria that make a ...
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides ... ppb,” said Mark Tess, PhD, Mycotoxin Product Manager for Charm ... and USDA-GIPSA inspection agencies that have a need to detect ... in a matter of minutes with nothing but our equipment ... and grain before accepting it, but they no longer have ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3
... Transposagen Biopharmaceuticals, Inc. ... has come to an agreement to expand its license for ... commercial applications. The intellectual property, owned jointly by the ... United States Department of Agriculture, enables facile genetic manipulation of ...
... , SOLANA BEACH, Calif., and HAMILTON, New Zealand, Oct. ... enzyme-based products for DNA extraction and other life sciences ... note documenting that its prep GEM® Insect DNA ... high-quality, ready-to-analyze DNA that is sufficient to serve as ...
... BlueFire Ethanol Fuels, Inc. (OTC Bulletin Board: BFRE), ... paradigm through the production of ethanol from non-food cellulosic ... planned biorefinery to Fulton, Mississippi. , (Logo: ... been awarded a $40 million dollar grant from the ...
Cached Biology Technology:Transposagen Expands Field of Use for piggyBac Technology 2Transposagen Expands Field of Use for piggyBac Technology 3ZyGEM Releases Data Confirming its prepGEM(R) Insect Kit is a Simple, Rapid Method for Extracting Insect DNA for Species Identification 2ZyGEM Releases Data Confirming its prepGEM(R) Insect Kit is a Simple, Rapid Method for Extracting Insect DNA for Species Identification 3ZyGEM Releases Data Confirming its prepGEM(R) Insect Kit is a Simple, Rapid Method for Extracting Insect DNA for Species Identification 4Department of Energy Grants BlueFire Approval for Site Change 2Department of Energy Grants BlueFire Approval for Site Change 3Department of Energy Grants BlueFire Approval for Site Change 4
(Date:8/28/2014)... A free mobile app called TX Invasives is now ... The University of Texas at Austin for identifying harmful ... , Invasive species in the United States cause about ... they destroy agricultural crops, clog waterways, kill native plants ... TX Invasives app for reporting where invasive species occur, ...
(Date:8/28/2014)... Entomological Society of America (ESA) is pleased to announce ... Member of the Society. Honorary Membership acknowledges those who ... significant involvement in the affairs of the Society that ... are selected by the ESA Governing Board and then ... be honored at the Awards Ceremony at Entomology 2014, ...
(Date:8/28/2014)... identified a handful of bacterial culprits that may drive ... ulcerative colitis, using patients, own intestinal immune responses as ... in the journal Cell . , Trillions of ... a critical role in the development and progression of ... of bacterial species affect a person,s susceptibility to IBD ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Yale study identifies possible bacterial drivers of IBD 2
... say they have assembled more completely the string of ... to imitate their owners and other sounds. The ... genome using a new technology, single molecule sequencing, and ... The team also decoded hard-to-sequence genetic material from corn ...
... by chemists in the Baruch ,60 Center for Biochemical ... to detail the individual steps of highly efficient reactions ... bacteria. In a paper published in the recent ... Energy & Environmental Science , the scientists ...
... from invasive species and the risk of wildfire is ... research on the Island of Hawaii. It is commonly ... species will restore the land to its original state. ... Invasions , Dr. Susan Cordell, USDA Forest Service Pacific ...
Cached Biology News:DNA sequenced for parrot's ability to parrot 2DNA sequenced for parrot's ability to parrot 3Rensselaer scientists unlock some key secrets of photosynthesis 2Rensselaer scientists unlock some key secrets of photosynthesis 3Native plant restoration not enough to maintain tropical dry forests in Hawaii 2
...
... pWEB::TNC™ Deletion Cosmid Cloning Kit enables you ... complete and unbiased primary cosmid library of ... nested deletion sublibraries. High efficiency cosmid library ... reproducible kit protocols. First, genomic DNA is ...
Mouse monoclonal antibody raised against a partial recombinant AATK. NCBI Entrez Gene ID = AATK...
... is a revolutionary multi-capillary electrophoresis system which ... It integrates sample loading, electrophoresis, and data ... the workflow and increasing the productivity of ... of using HDA system are:, No ...
Biology Products: