Navigation Links
Savient's Pegloticase Data in Treatment-Failure Gout Patients Presented at 72nd Annual Meeting of the American College of Rheumatology Conference
Date:10/27/2008

ition amounting to a severe gout syndrome, in a synthesis of data derived from five studies: the pegloticase Phase 2 study, GOUT 1, 2, and 3, and a 12-month non-interventional natural history study in treatment-failure gout patients. This was the first time that the data from these studies was presented in a scientific forum.

New Results presented at ACR:

-- The GOUT 3 study data demonstrated the continuing efficacy of

pegloticase in normalizing PUA to less than 6 mg/dL. It also

demonstrated the ability to maintain control of PUA for up to 18

months with continuous treatment in both the every 2 weeks and every 4

weeks treatment groups, in a proportion of patients similar to that

demonstrated in GOUT 1 and 2.

-- Gout Tophi: As previously reported by the Company, the superiority of

pegloticase administered every 2 weeks as compared to placebo in

attaining a gout tophus Complete Response was statistically significant

and clinically meaningful in the pegloticase 8mg every 2 weeks group

within 6 months of therapy, in the pre-specified pooled analysis.

Moreover, the tophus Complete Response was attained for the every 2

weeks group in both the GOUT 1 and GOUT 2 pivotal trials individually,

as well as in the pooled analysis. The pegloticase every 4 weeks group

attained statistical significance for tophus Complete Response in the

pre-specified pooled analysis. The analyses of secondary efficacy

endpoints for the individual studies as well as for the pooled data

across the two studies, has been included in the BLA submission for FDA

review.

The GOUT 3 data presented at ACR provided continued evidence of the

increase in pegloticase's favorable effect on achieving a Complete

Response for tophus resolution that was demonstrated in the initial 6

months of treatmen
'/>"/>

SOURCE Savient Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

2

GOOD

Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology technology :

1. One-Year Data Show Golimumab Improved Signs and Symptoms In Patients with Psoriatic Arthritis In Phase 3 Study
2. Intensive Lifestyle Intervention Program for Overweight or Obese Patients with Nonalcoholic Steatohepatitis Reduces Weight and Improves Overall Liver Health
3. UKs NICE Recommends Spinal Cord Stimulation for Patients with Chronic Neuropathic Pain
4. Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients
5. AdvanDxs PNA FISH(TM) Test Shown to Reduce Mortality by 42% for Patients With Hospital-Acquired Enterococcus faecium Bloodstream Infections
6. Poniard Announces Positive Incremental Efficacy and Safety Data from Phase 2 Picoplatin Trial in Patients With Metastatic Colorectal Cancer
7. Peregrine Pharmaceuticals Reports Progress in Its Phase II Trial of Bavituximab Plus Docetaxel in Patients With Advanced Breast Cancer
8. Novel Mass Spectrometry-based Assay Reveals Degradation and Low Levels of Bioactive B-type Natriuretic Peptide (BNP) in Patients with Heart Failure
9. Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure
10. DaVita Treats Thousands of Dialysis Patients in Wake of Hurricane Ike
11. Fujitsu PalmSecure and HT Systems PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Can economic incentives such as gift ... of the public to increase their donations of blood? ... Carey Business School Assistant Professor Mario Macis says ... large body of recent research that supports their argument, ... issue of Science that the World Health Organization and ...
(Date:5/23/2013)...  Rahal Letterman Lanigan Racing (RLL) and StemCyte, Inc., ... banking and therapeutics, announced today that StemCyte has become ... Indy car driven by James Jakes ... IndyCar 2013 season.   StemCyte, Inc. and Rahal ... of umbilical cord blood banking and its educational initiative ...
(Date:5/23/2013)... HILLS, Calif. , May 23, 2013  Saddleback ... recently became the first hospital on the ... robotic technology. This new surgical option provides women with ... Marc Winter , M.D., ... gynecologist and surgeon and medical director of minimally invasive ...
(Date:5/23/2013)... , May 23, 2013 Z Trim Holdings, ... ingredients to a variety of industries, announced that Chef ... panel discussion at this year,s National Restaurant Association ("NRA") ... on behalf of the Research Chefs Association.  Chef Ryan ... The Good, the Bad and the Ugly," joining four ...
Breaking Biology Technology:Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 3StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 2Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 3
... Oct. 31 ThermoGenesis,Corp. (Nasdaq: KOOL ), a ... stem cells, announced today it will report,financial results for ... November 6, 2008., Company,s Conference Call and Webcast, ... 6, 2008 at,2:00 PM Pacific (5:00 PM Eastern) to ...
... Corp. (OTC,Bulletin Board: SCOM) ("Sharps" or the "Company"), ... quantity generators of medical,waste, today announced the appointment ... Chief Operating Officer, effective October 27,2008. Mr. Grow, ... Board of Directors,since October of 2005, will retain ...
... Oct. 31 LI-COR Biosciences now offers,the LI-COR ... blot washing,and secondary antibody addition for Western blots. ... or multiple blots, the,LI-COR Blot Washer is an ... user-defined, preset wash cycles. Up to 20 presets ...
Cached Biology Technology:ThermoGenesis Corp. to Announce First Quarter Fiscal 2009 Results on November 6, 2008 2Sharps Compliance Corp. Announces Appointment of John R. Grow as President and Chief Operating Officer 2Sharps Compliance Corp. Announces Appointment of John R. Grow as President and Chief Operating Officer 3LI-COR Blot Washer Automates Western Blot Processing 2
(Date:5/24/2013)... studying noise in one French Quarter neighborhood of New ... municipal ordinances, Annette Hurley, PhD, Assistant Professor of Audiology ... Arriaga, a third-year LSUHSC doctor of audiology student, recommend ... hearing health. Their case study is published online in ... Management ., "An important part of an audiologist,s practice ...
(Date:5/23/2013)... , Automated conserved noncoding sequence (CNS) discovery ... grasses , Within the genome of each species, ... little change in position and sequence over millions of ... of these evolutionarily stable sequences, so-called conserved noncoding sequences ... genes or the condensation of chromosomes, but the function ...
(Date:5/23/2013)... per year, carrying more than 284 million tons of cargo, ... dollars in toll fees for the Panama Canal Authority. Each ... of water are used from Gatun Lake, which is also ... in the isthmus. , However, the advent of very ... the ships at sea, has demanded change. The Panama Canal ...
Breaking Biology News(10 mins):Please do try this at home 2Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3Reforestation study shows trade-offs between water, carbon and timber 2Reforestation study shows trade-offs between water, carbon and timber 3
... control everything of importance in biology. The genome rules all ... realizing that among the diverse forms of RNA, a kind ... other and with genes directly to manage the genome from ... by the vast stretches of DNA that do not code ...
... in a gene known as SOS1 account for many ... disorder which occurs in one in 1,000-2,500 live births. ... and learning disabilities, as well as heart problems and ... at Harvard Medical School-Partners Healthcare Center for Genetics ...
... on a person's ability to recover from a heart ... Nuclear Medicine. , "Using positron emission tomography (PET) and ... study the regenerative capacity of the heart's sympathetic nervous ... develop new nerves to replace damaged ones--is slower in ...
Cached Biology News:Peering into the shadow world of RNA 2Peering into the shadow world of RNA 3Study uncovers mutation responsible for Noonan Syndrome 2Diabetes slows nerve recovery after heart transplant 2
... Transcend Non-Radioactive Translation Detection Systems allow ... vitro. Using these systems, biotinylated lysine ... during translation, eliminating the need for ... amino acids. This biotinylated lysine is ...
...
... value of your microarray data using ... support you need from consultation to ... up to date methods. Utilize our ... Expression Profiling Service or from your ...
... the value of your microarray data using ... you need from consultation to extensive data ... methods. Utilize our expertise in combination with ... your own microarray experiments., ,Normalization and basic ...
Biology Products: