in blocks and in unstained slides. Serum samples from blood draws are also frozen. Samples may come from different locations in the patient’s body and at different times, she said. For example, in a trial of the drug Gleevec and dermatofibrosarcoma protuberans, surgeons took fresh-frozen tissue before the patient got chemotherapy and afterward to gauge the drug’s effect.
“We have 20 paired samples, and we’re now looking for money to analyze them," she said.
SARC’s scientific leadership decides who receives samples, she said. Those leaders are divided into three committees: developmental therapeutics, concept review and clinical research. Robert Maki, MD, PhD, medical director of the sarcoma program at Mount Sinai Medical Center in New York, is the director of translational research.
“He moves among the committees; he’s the glue that holds them together,” Reinke said.
“The samples are being collected with annotated information along the way.” She said this includes the patient’s age, treatment, the response to treatment, survival, the location of the tumor, when the sample was taken, and whether the sample came from the original tumor or a metastasis. “Having annotated information is a critical component.”
Samples are stored at the biorepository at Nationwide Children’s Hospital in Columbus, Ohio, where SARC has bought space. Cooperative groups for other cancers save samples there, too, she said.
SARC doesn’t store all of its samples, Reinke said. “It costs to collect, save and analyze samples. In our IGF1R trial, for example, we had 25,000 serum samples." SARC’s scientific leadership decided they needed to keep only a third of those.
Comprehensive sarcoma centers also save biospecimens, often tied to patient details, said Dafydd G. Thomas, PhD, MD, co-director of the University of Michigan's Molecular Pathology Research Laboratory and its cancer center's Tissue and Molecular Pathology Core in
Page: 1 2 3 Related biology technology :1
Copyright©2012 Vocus, Inc.
All rights reserved
. Sarcoma Alliance Excited About New Drug Research2
. Study Scavenger and JALR.org Announce Alliance Utilizing Smart Phone Capabilities to Bring Clinical Trials to Motivated Subjects3
. The Pistoia Alliance Releases HELM Biomolecular Representation Standard Open Source Tools4
. Edison Expands French Healthcare Sector Coverage With Initiation of Coverage on BioAlliance Pharma5
. Smart Consulting Group and The Catalyst Group Form Alliance to Supply Quality Compliance Consulting Services For the Pharmaceutical Industry6
. VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials7
. Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC8
. The Alliance for the Advancement of Adult Stem Cell Therapy and Research Recently Has Proven Stem Cells To Be Effective in Dilated Cardiomyopathy9
. Emergent Technologies and Caisson Biotech Form Strategic Alliance with Local Health Care Providers to Improve Delivery and Performance of a Therapeutic Drug10
. ClearPath Workforce Management CEO Appointed Co-chair of Northern California Leadership Forum for Woman Owned Business Alliance11
. Campbell Alliance to Release New Forward-Looking Industry Report on Deal-Making Trends at the 2013 BIO International Convention