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Santaris Pharma A/S Forms Strategic Alliance With Shire plc to Develop RNA-Based Medicines for the Treatment of Rare Genetic Disorders
Date:8/24/2009

n of certain initial studies. The initial term of the research collaboration is two years; Shire has an option to extend for up to two additional years.

"We are delighted that the increasing interest in the LNA Drug Platform and our Drug Discovery Engine so quickly has materialized in our fourth strategic alliance. The alliance with Shire demonstrates the broad utility of Santaris Pharma's proprietary LNA Drug Platform for developing treatments for an extensive range of diseases, now also including rare genetic disorders," said S0ren Tulstrup, President and CEO of Santaris Pharma A/S. "This fourth partnership follows only seven months after the announcement of our new strategic alliance with Wyeth Pharmaceuticals and further demonstrates our leading position in the rapidly evolving RNA-based therapeutics field."

In addition to these initial payments Santaris Pharma A/S will receive funding for all additional discovery activities to be performed under the contract, payments on Shire's nomination of up to two additional targets, and will be eligible to receive development, regulatory and sales related milestone payments of up to US$72 million for each of the potential five drug candidates and customary royalties on the worldwide sales of commercialized products arising from the alliance.

"We are excited to be collaborating with Santaris Pharma A/S, a leader in the field of RNA-based therapeutics. Its LNA technology and experienced management team are a good fit for Shire," said Dr. Whaijen Soo, Senior Vice President, Research and Development, Shire Human Genetic Therapies. "We look forward to working closely with the Santaris Pharma A/S team and expanding our pipeline by discovering and developing new RNA-based medicines to treat rare genetic disorders."

Santaris Pharma A/S' worldwide strategic alliance with Shire to discover and develop new medicines targeting rare genetic disorders adds t
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