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Sanofi-aventis Announces Second Quarter 2009 Results
Date:7/29/2009

(R)) versus NPH insulin on progression of retinopathy in patients with type 2 diabetes. These results demonstrated that the two treatments showed similar effects on the progression of retinopathy and provided similar overall safety. There was no observable difference in terms of serious adverse events, including cancer.

On July 23 2009, The CHMP has re-confirmed their initial assessment of Lantus((R)), based on an in-depth review of existing evidence and of the recent publications of registry analyses in Diabetologia. All four registry analyses were found to have significant methodological limitations and to provide inconsistent and inconclusive results regarding a potential link between Lantus((R)) use and an increased risk of cancer. The CHMP concluded that the available data does not provide a cause for concern and that changes to the prescribing advice for Lantus((R)) are therefore not necessary.

Sanofi-aventis will implement a set of actions to develop further research in this area in line with the request of CHMP. These actions take into account the recommendations recently made by an independent team of interdisciplinary medical experts on this subject.

Since publication of the Diabetologia registry analyses, there have been no significative changes in prescription trends of Lantus((R)) thus far.

Second-quarter net sales of the rapid-acting insulin analog Apidra((R)) were up 54.5% at euro 35 million, lifted by the launch of Apidra((R)) SoloSTAR((R)) in the United States. First-half net sales of Apidra((R)) were up 48.8% at euro 66 million.

Lovenox((R)), the leading low molecular weight heparin on the market, returned to robust growth in the second quarter of 2009 with net sales up 13.3% at euro 780 million thanks to good performances in Europe (up 22.4% at euro 226 million) and
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