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Sanofi-aventis Announces Second Quarter 2009 Results
Date:7/29/2009

uld provide significant scope for value creation through external growth opportunities targeting a return above cost of capital.

(6) Before the impact of inflation and any significant change to the activities of the Group, at constant exchange rates

Research and Development

During the second quarter of 2009, initiatives continued to transform the Group's Research and Development operations, with a view to continuing to refocus on innovation, gaining flexibility, and reorienting some of its existing resources to external collaborations.

On April 29, 2009, the results of the complete, in-depth review of the R&D portfolio conducted as part of the sanofi-aventis transformation program were announced. The main changes in the portfolio since that date are:

  • 4 new candidates entered Phase I:
    • SAR548304 (biliary acid reabsorption inhibitor), developed for hypercholesterolemia, and SAR153192, an anti-DLL4 monoclonal antibody developed for cancer
    • XL147 (orally-administered PI3K inhibitor) and XL765 (orally-administered double PI3K and target mTOR inhibitor), developed for cancer: sanofi-aventis has obtained an exclusive world license for both of these products, which were developed by the biotechnology company Exelixis
  • SAR 407899, a rho-kinase inhibitor, entered Phase II in erectile dysfunction.
  • BSI-201, a PARP inhibitor, developed by BiPar Sciences (recently acquired by sanofi-aventis) entered Phase III in July. This pivotal study will evaluate the product in association with chemotherapy in women with metastatic triple negative breast cancer (mTNBC), i.e. with a tumor that expresses neither the estrogen receptor nor the progesterone receptor and does not over-express the HER2 receptor.
  • Enrolment to the Phase III study, evaluating NV1FGF in critical ischemia of t
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