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Sanofi Pasteur's Investigational H5N1 Influenza Vaccine Achieves High Immune Response at low Dosage
Date:9/17/2007

LYON, France, September 18 /PRNewswire-FirstCall/ --

- Clinical Study Demonstrates Breakthrough Dose-Sparing Formulation That Increases Stockpile Capacities and Expands Potential Production Capacities to Billions of Doses in a Pandemic Situation

Sanofi pasteur, the vaccines division of sanofi-aventis Group, today announced data showing that its new investigational H5N1 pandemic influenza vaccine containing a proprietary adjuvant achieved a high immune response at the lowest dose of H5N1 antigen reported to date.

The vaccine containing only 1.9 micrograms of antigen generated a high level of seroprotective immune response in over 70 percent of the participants in a clinical trial and, in the same clinical trial, vaccine containing 3.75 micrograms of antigen generated a high level of seroprotective immune response in over 80 percent of the participants.

Once fully developed, this vaccine should give sanofi pasteur the potential to provide billions of doses in a pandemic situation and greatly increases its ability to produce vaccines for stockpiling in advance of a pandemic. This would be a significant achievement for public health and a breakthrough in research and development of pre-pandemic and pandemic vaccines that is fully in line with sanofi pasteur's early commitment to bring answers to the global threat posed by pandemic influenza.

Results are based on analysis of a clinical trial conducted in Belgium. The trial involved 266 healthy adults, 18 to 40 years of age. The vaccine tested was produced from inactivated H5N1 virus and contains a new, proprietary adjuvant aimed at stimulating the immune system to increase the response to the vaccine. Trial participants received two doses of each formulation. Four levels of antigen dose were tested, with 1.9 micrograms being the lowest dose.

Preliminary data also show good cross-reactivity to a more recently circulating H5N1 strain. Further assessment of the ability of this vacc
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SOURCE Sanofi Pasteur
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