Navigation Links
Sangart, Inc. Receives European Orphan Drug Designation for the Use of MP4CO in Patients With Sickle Cell Disease
Date:12/9/2009

new therapeutic option to patients suffering from sickle cell crisis."

About MP4CO

Sangart's product platform is based on the MP4 molecule, an investigational biopharmaceutical product designed to enhance the perfusion of oxygen-deprived (ischemic) tissues and provide targeted oxygen delivery in the capillaries. Carbon monoxide (CO) at very low doses stabilizes hemoglobin S and acts as a messenger to cells, reducing inflammation, reducing oxygen requirements and preventing programmed cell death. The MP4 molecule can be modified to carry CO and other gases to enhance therapeutic benefit for certain patients. MP4CO is designed to deliver therapeutic, non-toxic levels of CO providing an immediate metabolic signal to cells and reducing inflammation. Once the CO is released from the compound, the MP4 molecule is oxygenated in the lung and then delivers oxygen to the ischemic tissues.

MP4CO is made in the same manner as MP4OX, with the only difference being that a CO molecule is attached in place of oxygen in order to provide an additional therapeutic benefit to the patient.

About Sickle Cell Disease

Sickle cell disease is a genetic disorder that affects red blood cell circulation in millions of people around the world, including approximately 70,000 people in the United States and between 40,000 and 50,000 people in the European Union.

Sickle cell disease is caused by an inherited hemoglobin disorder. Healthy red blood cells are disk shaped and can deform and move through small blood vessels to carry oxygen to all parts of the body. In sickle cell disease, as red blood cells circulate and oxygen is released in the circulatory system, the deoxygenated abnormal hemoglobin S polymerizes. When this occurs, the red blood cells can become sticky and elongated to look like a C-shaped farm tool called a 'sickle'. These sickled
'/>"/>

SOURCE Sangart, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Sangart, Inc. Completes Enrollment in Second Phase III Study of Hemospan, a Novel Oxygen Transport Agent
2. Sangart, Inc. Announces Key Executive Appointments and Company Restructuring
3. Sangart, Inc. Completes Series F Funding Round
4. Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis
5. Ciphergen Biosystems Receives Noncompliance Letter From The Nasdaq Stock Market
6. Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy
7. Anesiva Receives FDA Approval for Zingo(TM), a New, Innovative Product to Reduce Pain Associated with Needle Insertion Procedures in Children
8. IsoTis Receives FDA Clearance for Accell Family of Products
9. Actavis Receives Approval of Fentanyl Transdermal System in the U.S.
10. AGA Medical Corporation Receives FDA and CE Mark Approvals for the AMPLATZER Vascular Plug II
11. IDM Pharma Receives Not Approvable Letter for Mifamurtide (L-MTP-PE) for the Treatment of Osteosarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... PARIS , July 1, 2015 ... key developer of biotech crops, today announce a ... generations of insect control traits. "Growers ... the realities of advancing insect resistance. We are ... insect control technology with Genective,s capability in developing ...
(Date:7/1/2015)... Colo. and BANGALORE, India ... global genomic profiling company that uses next generation sequencing ... of Scott A. Storrer as chief executive ... CEO, he will be responsible for all strategy, business ... Chandru , who has served as Strand,s chairman and ...
(Date:7/1/2015)... , July 1, 2015 Isagenix International, ... has earned three Gold, three Silver, and three Bronze ... gala held in Chicago this ... the premier business awards program in the U.S. ... our company,s strength in developing leaders, cultivating talent, creating ...
(Date:7/1/2015)... ... 2015 , ... Apex Therapeutics announced today that company CEO, David Broecker provided ... , The presentation took place on Tuesday, June 16 and provided an update on ... for the treatment of pancreatic cancer. A copy of the company overview can ...
Breaking Biology Technology:AgBiome and Genective collaborate to create novel insect-resistant crops 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2
... of California, Berkeley, researchers have taken genes from grass-eating fungi ... from tough plant material cellulose that normal yeast ... the biofuels industry, which is struggling to make cellulosic ethanol ... economically feasible. "By adding these genes to yeast, ...
... available in German . , Behind every coincidence ... least. In principle, every event, including the fall of dice or ... mathematical terms. Researchers at the Max Planck Institute for the Physics ... the principle of true randomness. With the help of quantum physics, ...
... Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ... for human disease, announced today that Dr. Arthur ... present at the Stifel Nicolaus Healthcare Conference in Boston ... Time. A live webcast of the presentation ...
Cached Biology Technology:Researchers expand yeast's sugary diet to include plant fiber 2Researchers expand yeast's sugary diet to include plant fiber 3Researchers expand yeast's sugary diet to include plant fiber 4Random numbers game with quantum dice 2Random numbers game with quantum dice 3Random numbers game with quantum dice 4Lexicon to Present at Stifel Nicolaus Healthcare Conference 2
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., a ... by the United States Patent and Trademark Office (USPTO) ... process leverages TAKE Solutions, Clinical Accelerators to reduce the ... (when compared to standardization without the accelerators), thus reducing ... At the heart of the patented ...
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
(Date:6/24/2015)... June 22, 2015 ... addition of the "Huawei Ascend Mate 7 ... to their offering. Huawei,s technological choice ... opposite direction than Apple,s and Samsung,s one. The ... developed by Fingerprint Cards, a main actor in ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... once thought to lie outside the reach of science, ... Medical Center have captured and sequenced tiny pieces of ... protein fragments—seven in all—appear to most closely match amino ... lending support to a recent and still controversial proposal ...
... study by researchers led by Kurt Kroenke, M.D., of the ... reports that nearly 20 percent of patients seen by primary ... outlines the effectiveness of a new screening tool which can ... or more anxiety disorders. The study is published in ...
... the genome sequence of the rhesus macaque monkey and ... April 13 in a special section of the journal ... share about 93 percent of their DNA, yet have ... paper, the Rhesus Macaque Genome Sequence and Analysis Consortium, ...
Cached Biology News:Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex 2Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex 3Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex 4Anxiety disorders surprisingly common yet often untreated 2Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps 2Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps 3
iEMS Thermal Microplate Holder...
...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... oligonucleotides: PTOs are internucleotide modifications, ... backbone is replaced by a sulphur atom. ... degradation. PTOs are available as ... Oligonucleotides with thio-caps ...
Biology Products: