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Sangart, Inc. Receives European Orphan Drug Designation for the Use of MP4CO in Patients With Sickle Cell Disease
Date:12/9/2009

new therapeutic option to patients suffering from sickle cell crisis."

About MP4CO

Sangart's product platform is based on the MP4 molecule, an investigational biopharmaceutical product designed to enhance the perfusion of oxygen-deprived (ischemic) tissues and provide targeted oxygen delivery in the capillaries. Carbon monoxide (CO) at very low doses stabilizes hemoglobin S and acts as a messenger to cells, reducing inflammation, reducing oxygen requirements and preventing programmed cell death. The MP4 molecule can be modified to carry CO and other gases to enhance therapeutic benefit for certain patients. MP4CO is designed to deliver therapeutic, non-toxic levels of CO providing an immediate metabolic signal to cells and reducing inflammation. Once the CO is released from the compound, the MP4 molecule is oxygenated in the lung and then delivers oxygen to the ischemic tissues.

MP4CO is made in the same manner as MP4OX, with the only difference being that a CO molecule is attached in place of oxygen in order to provide an additional therapeutic benefit to the patient.

About Sickle Cell Disease

Sickle cell disease is a genetic disorder that affects red blood cell circulation in millions of people around the world, including approximately 70,000 people in the United States and between 40,000 and 50,000 people in the European Union.

Sickle cell disease is caused by an inherited hemoglobin disorder. Healthy red blood cells are disk shaped and can deform and move through small blood vessels to carry oxygen to all parts of the body. In sickle cell disease, as red blood cells circulate and oxygen is released in the circulatory system, the deoxygenated abnormal hemoglobin S polymerizes. When this occurs, the red blood cells can become sticky and elongated to look like a C-shaped farm tool called a 'sickle'. These sickled
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SOURCE Sangart, Inc.
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