Navigation Links
Sangamo BioSciences and CHDI Foundation Announce Collaboration to Develop ZFP Therapeutic® for Huntington's Disease
Date:4/5/2011

RICHMOND, Calif. and NEW YORK, April 5, 2011 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) and CHDI Foundation, Inc. have announced a collaboration to develop a novel therapeutic for Huntington's disease (HD) based on Sangamo's proprietary zinc finger DNA-binding protein (ZFP) technology. The ZFP therapeutic approach will target the huntingtin gene that causes HD, an inherited neurodegenerative disease for which there are currently no therapies available to slow disease progression.

“We’re very excited to bring Sangamo’s ZFP technology platform to Huntington’s disease,” said Ignacio Munoz-Sanjuan, Ph.D., Vice President, Biology at CHDI. “Our collaboration aims to develop ZFP transcription factors that will alter huntingtin expression, which has the potential to directly modify disease progression. Moreover,  the versatility of  ZFP technology makes it a powerful platform that can be deployed to impact various aspects of HD pathology and we look forward to working with Sangamo to develop  multiple innovative therapeutic approaches for HD.”

"We are very pleased to be collaborating with CHDI, who bring tremendous experience and resources in HD to the development of a novel ZFP Therapeutic for this devastating disease," said Philip Gregory, D. Phil, Sangamo's vice president, research and chief scientific officer. "The causative genetic defect in HD - mutations in the huntingtin gene - provides a validated target for intervention using a ZFP-based approach.  Our collaboration will initially focus on developing ZFP Therapeutics to lower the levels of the mutant huntingtin protein in mouse and human cells.  This collaboration highlights the unique ability of our ZFP technology to drive potentially therapeutic outcomes at the genetic level."

"The addition of a program in HD expands our
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Sangamo BioSciences Announces Presentation at the 10th Annual Needham Healthcare Conference
2. Sangamo BioSciences Reports Fourth Quarter and Full Year 2010 Financial Results
3. Sangamo BioSciences Announces Fourth Quarter and Full Year 2010 Conference Call and Webcast
4. Sangamo BioSciences Announces Presentation at J.P. Morgan Healthcare Conference
5. Sangamo BioSciences Announces Data Presentation of First In Vivo Demonstration of ZFN-mediated Gene Correction Via Systemic Delivery at American Society for Hematology Meeting
6. Sangamo BioSciences Awarded Grants for the Development of Four ZFP Therapeutic® Programs
7. Sangamo BioSciences Announces Third Quarter 2010 Conference Call and Webcast
8. Sangamo BioSciences Announces Presentation at Two Upcoming Investor Conferences
9. Sangamo BioSciences Announces Second Quarter 2010 Conference Call and Webcast
10. Sangamo BioSciences Announces Presentation at Two Upcoming Investor Conferences
11. Sangamo BioSciences and Collaborators Present Data in Fifteen Presentations Highlighting Broad Therapeutic Applications of ZFP Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... A major challenge before new biotechnology start-up ... of Boston-Cambridge, is gaining visibility that can lead to ... Director of Boston’s Adult Stem Cell Technology Center, LLC ... of his company an important priority since he started ... a social media marketing campaign launched earlier ...
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... 28, 2014 Best Sanitizers, Inc., the ... alcohol-based hand sanitizer, asks food processors and food handling ... hand sanitizer they’re currently using to Best Sanitizers’ ... is critical to fighting cross-contamination and the spread of ... believes there are key criteria that make a hand ...
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... ... line of Spectrum benchtop laboratory equipment that is now available for the budget-conscious researcher ... baths, mini centrifuges, hotplates & magnetic stirrers for general sample preparation and laboratory mixing ... Gardena, ...
... ... general release , ... Charlottesville, VA, San Francisco, CA, New York, NY and Paris, France (PRWEB) January 8, ... software solution for managing and reporting aggregate spend. The company will be officially launching ...
... , , HAYWARD, Calif., Jan. 8 ... that it has obtained commitments from accredited institutional investors ... and warrants in a private placement. The financing was ... Great Point Partners along with participation from other existing ...
Cached Biology Technology:Spectrum Introduces New Line of Spectrum Branded Benchtop Laboratory Equipment 2OpenQ Announces openSpend for Physician Payment Sunshine Act Compliance 2Solta Medical to Raise $17.2 Million in Private Placement 2Solta Medical to Raise $17.2 Million in Private Placement 3Solta Medical to Raise $17.2 Million in Private Placement 4Solta Medical to Raise $17.2 Million in Private Placement 5
(Date:8/28/2014)... Research Careers) Program has announced the travel award recipients ... 18 22, 2014 in San Diego, California. ... students, post doctorates and scientists from underrepresented groups into ... encourage the participation of young scientists at the American ... 16 awards totaling $29,600., The FASEB MARC Program is ...
(Date:8/28/2014)... developmental on-off switch for Streptomyces , a group ... the world,s naturally derived antibiotic medicines. , Their ... possible to manipulate this switch to make nature,s antibiotic ... 28 in Cell , found that a unique ... larger protein called BldD ultimately controls whether a bacterium ...
(Date:8/28/2014)... method for measuring and imaging how quickly blood flows ... understand how drug abuse affects the brain, which may ... lead to better treatment options for recovering drug addicts. ... from Stony Brook University in New York, USA and ... in The Optical Society,s (OSA) open-access journal ...
Breaking Biology News(10 mins):Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3
... flying in chevron formation or cyclists learned the value of ... their spores so as to spread them as high and ... Sclerotinia sclerotiorum , spews thousands of spores nearly simultaneously to ... even creates a wind that carries many of the spores ...
... to clean water and environmental causes, his dedication as ... the pursuit of discovery, Professor Xiaoguang Meng received an ... Technology at the university,s annual Convocation Ceremony on September ... Charles V. Schaefer, Jr. School of Engineering and Science, ...
... is now open to the press for the ... of America (ESA) and National Education Association, with ... October 14-15, 2010 in Washington, D.C. The summit ... educators, scientists, and policy professionals from a wide ...
Cached Biology News:Fungal spores travel farther by surfing their own wind 2Fungal spores travel farther by surfing their own wind 3Fungal spores travel farther by surfing their own wind 4Prof. Xiaoguang Meng receives honorary master of engineering from Stevens 2Prof. Xiaoguang Meng receives honorary master of engineering from Stevens 3Ecology and Education Summit to address environmental literacy 2
... units/µL ,• High specific activity and processivity ... 'A' overhang ,• Processes ... high activity in primer extension and other ... of the enzyme, each lot has been ...
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/L; 1 tube of 1, 000 units enzyme/tube w/Buffer II and MgCl2...
... 5 units/µL ,• High specific activity and ... an 'A' overhang ,• Processes ... high activity in primer extension and other ... of the enzyme, each lot has been ...
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/uL; 25 tubes of 1, 000 units enzyme/tube w/ Buffer I...
Biology Products: