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Sangamo BioSciences Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research
Date:5/4/2009

>Nat Biotechnol. 2008 Jul; 26(7):808-16). A Phase 1 clinical trial is ongoing at the University of Pennsylvania to evaluate the safety and tolerability of SB-728-T, a ZFP Therapeutic based on Sangamo's CCR5-disrupting ZFNs. SB-728-T is being tested as an ex-vivo, or cell-therapy, approach for the treatment of HIV/AIDS.

Sangamo proposes to develop the next generation of this therapeutic approach, an in-vivo, or direct injection protocol. The resulting CCR5-negative cells will be protected from HIV infection and have the potential to provide long term control of the opportunistic infections characteristic of AIDS as well as HIV itself. Ultimately this approach could be combined with traditional vaccination strategies to further arm the immune system against HIV infection.

"We are very pleased that our research proposal was chosen for this prestigious award," commented Edward Lanphier, Sangamo's president and CEO. "We already have an ongoing Phase 1 clinical trial to evaluate our ZFN-based approach as an ex-vivo formulation. This grant will aid our efforts to develop the next generation of this ZFP Therapeutic, an in-vivo formulation for direct injection that could make our approach accessible to HIV-infected patients throughout the world."

"The winners of these grants are doing truly exciting and innovative work," said Dr. Tachi Yamada, president of the Gates Foundation's Global Health Program. "I'm optimistic that some of these exploratory projects will lead to life-saving breakthroughs for people in the world's poorest countries."

About Grand Challenges Explorations

Grand Challenges Explorations is a five-year, $100 million initiative of the Gates Foundation to promote innovation in global health. The program uses an agile, streamlined gra
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SOURCE Sangamo BioSciences, Inc.
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