Navigation Links
Sangamo BioSciences Presents Data Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic
Date:9/18/2007

About HIV/AIDS and CCR5

HIV stands for Human Immunodeficiency Virus. HIV infection kills or impairs cells of the immune system, progressively destroying the body's ability to fight infections and certain cancers resulting in AIDS (Acquired Immune Deficiency Syndrome). Individuals diagnosed with AIDS are susceptible to life-threatening diseases called opportunistic infections, which are caused by microbes that usually do not cause illness in healthy people. According to Worldaidsday.org, over 3 million people were infected with HIV in 2005. There are now over 40 million people living with HIV and AIDS worldwide.

CCR5 is the chemokine receptor that HIV uses as a co-receptor to gain entry into immune cells. CCR5 is perhaps the most important of the known co-receptors for HIV, since the most commonly transmitted strains of HIV are strains that bind to CCR5 -- so-called "R5" strains. A small fraction of the population carries a mutation in their CCR5 gene, called the delta32 mutation. This mutated version of the gene produces malformed CCR5 proteins, which cannot be used by HIV as a co-receptor. Individuals that have mutant delta32 versions of both of their CCR5 genes are resistant to infection by R5 HIV strains.

About Sangamo

Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therapeutic(TM) development program is currently in Phase 2 clinical trials for evaluation of safety and clinical effect in patients with diabetic neuropathy. Phase 1 clinical trials are ongoing to evaluate a ZFP Therapeutic for peripheral artery disease. Other therapeutic development programs are focused on cancer and HIV/AIDS, neuropathic pain, nerve regeneration, Parkinson's disease and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related biology technology :

1. Perscitus Biosciences secures $250K Commerce loan
2. Wisconsin biosciences rise to the challenge
3. Quintessence Biosciences advances cancer drug
4. Quintessence Biosciences names new president
5. Caden Biosciences may signal critical mass
6. Wisconsin start up Primorigen Biosciences corrals out-of-state investment
7. WARF signs licensing pact with BD Biosciences
8. Fisher Biosciences contracts with Madison-based GenTel BioSurfaces
9. State awards QRG Biosciences development grant
10. EMD Biosciences partners with European biotech company
11. Quintessence Biosciences forms cancer therapeutic advisory board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/5/2008)...valuable if we possess it in large-sized pieces. H... for those interested in exploiting gold,s excepti...l reactions, including the oxidation of poisonous ...at room temperatures. That process, if industriali...f catalytic converters that clean automobile exhau...
(Date:9/5/2008)... 5 /- Men living in Western,Oregon wh...rged prostate,now have the option of out-patient, ... Inc. is pleased to announce that a network of doc...rough LIFE(TM) (Laser Induced,Flow Enhancement) la...),that quickly and gently eliminates swollen prost...
(Date:9/5/2008)...RNewswire-FirstCall/ -- Abbott (NYSE: ABT ),will ...onference on Friday,Sept. 12, 2008, in London. Jo...will make a formal presentation on the company at ... audio webcast of the presentation will be accessi...t http://www.abbottinvestor.com . An,archived edi...
(Date:9/5/2008)...e-FirstCall/ - Ondine Biopharma,Corporation (TSX: ...oping,photodisinfection-based products, today anno... the Treatment of Chronic Periodontitis" will be,p...n Academy of,Periodontology,s (AAP) annual meeting...hington State Convention and Trade Center in Seatt...
Breaking Biology Technology:NIST and partners identify tiny gold clusters as top-notch catalysts 2Revolutionary New In-Office EVOLVE(R) Laser Prostate Treatment Available Throughout Western Oregon 2Ondine Announces Presentation of Positive Clinical Trial Results at the American Academy of Periodontology's 94th Annual Meeting 2
...Madison, Wis. — As a former attorney and cu...search Foundation (WARF), Carl Gulbrandsen certain...sks facing the U.S. Patent and Trademark Office an...ntly began serving a three-year term, have even hi...,s a very daunting thing," said Gulbrandsen, who n...
... Small Times magazine has just put out in its Ma... the U.S. Its focus is primarily on the environmen...and microtechnology companies, which will include ...tics. , ,Before I provide you with their results, ... compute their ranking. They looked at these facto...
...he University of Wisconsin,s Condor software proje... computing system at European research heavyweight...as a computing network with more than 100 sites in...uilding a grid with more than 10,000 processors, w...cessible for large-scale projects even as each loc...
... Given what passes for appropriate business attire... made a big deal out of "casual Fridays." , ,(In t... my own professional attire trajectory has gone th...at Digital Equipment Corporation, I was once asked...ur building.) , ,If you need any more evidence tha...
Other Biology Technology:Gulbrandsen tackles 'daunting' challenges in Patent Office 2Midwest states in top 10 small-tech hotspots 2Dressing information technology in business clothes 2Dressing information technology in business clothes 3
(Date:9/4/2008)..., 5 September 2008 Even scientists define ,a gene...e that the media also have various ways of framing...ppearing in the October 2008 issue of EMBO report... analysis of 300 articles in British and Norwegian...ail from the UK; and Aftenposten, Dagbladet, and V...
(Date:9/4/2008)..., Sept. 4, 2008 As the anniversary of the Septemb...ciety (ACS) has issued a new podcast describing an...ety and national security. The podcast is the six...hemistry Solutions )series. , With new episodes ...aunting problems facing society in the 21st Centur...
(Date:9/4/2008)...mputer model help stabilize the tuna population? C...thout jeopardizing food production? , Those and ...ists, applied mathematicians, economists, biologis...rnell University,s new Institute for Computational... grant from the National Science Foundation (NSF)....
(Date:9/4/2008)... Mass., Sept. 4, 2008 Declaring the success of an...opy, Los Angeles-based philanthropists Eli and Edy... their total gift to the Broad Institute of Harvar...s gifts totaling $200 million, the Broads today ga...titute, which had been launched as a 10-year "vent...
Breaking Biology News(10 mins):What is a gene? 2New 'chemical radar' among national security innovations in ACS podcast 2New 'chemical radar' among national security innovations in ACS podcast 3Cornell gets $10 million NSF grant to establish new sustainability institute 2Eli and Edythe L. Broad make unprecedented gift to endow Broad Institute of Harvard & MIT 2Eli and Edythe L. Broad make unprecedented gift to endow Broad Institute of Harvard & MIT 3Eli and Edythe L. Broad make unprecedented gift to endow Broad Institute of Harvard & MIT 4Eli and Edythe L. Broad make unprecedented gift to endow Broad Institute of Harvard & MIT 5Midwest Meets West Coast The Chicago School of Professional Psychology to Open New Campus in Downtown Los Angeles 13090 1Midwest Meets West Coast The Chicago School of Professional Psychology to Open New Campus in Downtown Los Angeles 13090 2Midwest Meets West Coast The Chicago School of Professional Psychology to Open New Campus in Downtown Los Angeles 13090 3Midwest Meets West Coast The Chicago School of Professional Psychology to Open New Campus in Downtown Los Angeles 13090 4California Dental Hygienists Offer Tips for Safe Sippy Cup Use 13089 1California Dental Hygienists Offer Tips for Safe Sippy Cup Use 13089 2Belden Appoints Mary S McLeod of Pfizer Inc to Board of Directors 13087 1Belden Appoints Mary S McLeod of Pfizer Inc to Board of Directors 13087 2URAC Invites Health Management Industry Public for Comments on Changes to Its Core Accreditation Standards 13085 1URAC Invites Health Management Industry Public for Comments on Changes to Its Core Accreditation Standards 13085 2URAC Invites Health Management Industry Public for Comments on Changes to Its Core Accreditation Standards 13085 3
...or the first time, researchers have enticed transp... in the spinal cord to connect with muscles and pa... study suggests that similar techniques may be use...ury, transverse myelitis, amyotrophic lateral scle...y was funded in part by the NIH,s National Institu...
... computer model newly developed by researchers com...sting to help scientists predict animal dispersion...s across the Caribbean Sea. The work is reported b...nford University, and Donald B. Olson of the Unive...ue of Current Biology, published by Cell Press. ...
...he ability to spot venomous snakes may have played...d humans, according to a new hypothesis by Lynne I...work is published in the July issue of the Journal... enlarged brains, and grasping hands and feet, and...Scientists have thought that these characteristics...
...n a finding that broadens our understanding of tim...ve discovered that an insect pollinator, the bumbl.... Although many insects show daily and annual rhyt... estimate the duration of shorter time intervals h...vertebrates. , The findings are reported by Mich...
Other Biology News:Neurons grown from embryonic stem cells restore function in paralyzed rats 2Neurons grown from embryonic stem cells restore function in paralyzed rats 3Neurons grown from embryonic stem cells restore function in paralyzed rats 4Seeing the serpent 2
...IRECT is a single-step staining method for labelin...ometry. The kit contains all the key reagents requ...ositive and negative control cells for assessing r...buffers for processing individual steps in the ass...
...ioGenex VISION Sytem is a highly advanced digital ... imaging and automation technology that is designe...g/retrieval and colored professional reporting. Th...scanning and detection modules for automated tissu...
The PowerPac HV high-voltage power supply, with temperature probe, 100-120 and 220-240 V, supports an increased output of 5,000 V, 500 mA, and 400 W. The temperature probe is used to monitor gel temp
The Model 111 mini IEF cell is an apparatus dedicated to general analytical isoelectric focusing (IEF) using polyacrylamide or agarose slab gels. The cell includes the electrophoresis chamber and lid
Biology Products: