Navigation Links
Sangamo BioSciences Presents Data Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic
Date:9/18/2007

cer. "Most importantly, we have demonstrated that a single treatment with our CCR5-specific ZFNs generates a population of HIV-resistant T-cells similar to the situation in individuals carrying the natural CCR5-delta32 mutation. We have shown that these ZFN-modified cells are made permanently resistant to HIV. Furthermore, the cells selectively survive and expand in an animal after HIV infection providing a reservoir of healthy and uninfectable immune cells. In a patient, such cells could be available to fight both opportunistic infections and HIV itself. In addition, we have reported on the successful ZFN-modification of clinical-scale quantities of human CD4 T-cells. The modified cells exhibited the expected properties of normal CD4 T-cells minus a functional CCR5 receptor. This demonstrates that ZFN-modified human CD4 T-cells can be produced in the quantities required for the translation of this program into the clinic which is our immediate goal for this ZFP Therapeutic."

Several major pharmaceutical companies have initiated programs to develop small molecule or antibody approaches to block the binding of HIV to CCR5. However, a small molecule or antibody approach requires the constant presence of a sufficiently high concentration of drug to block therapeutically relevant numbers of the CCR5 protein, which is present in thousands of copies on the surface of each T-cell and other tissues in the body. One such drug was recently approved by the US Food and Drug Administration with a "black box" warning, the strongest for prescription drugs, concerning the risk of liver toxicity and the possibility of heart attacks.

Sangamo's ZFN technology represents a means of potentially circumventing these limitations or risks by specifically modifying only CD4 T-cells, the principal target of HIV pathology, in a one-time exposure of the cells to ZFNs. This results in permanent modification of the CCR5 protein so that HIV cannot enter and infect the cells. This appro
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Perscitus Biosciences secures $250K Commerce loan
2. Wisconsin biosciences rise to the challenge
3. Quintessence Biosciences advances cancer drug
4. Quintessence Biosciences names new president
5. Caden Biosciences may signal critical mass
6. Wisconsin start up Primorigen Biosciences corrals out-of-state investment
7. WARF signs licensing pact with BD Biosciences
8. Fisher Biosciences contracts with Madison-based GenTel BioSurfaces
9. State awards QRG Biosciences development grant
10. EMD Biosciences partners with European biotech company
11. Quintessence Biosciences forms cancer therapeutic advisory board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... At the 11th hour, ... the shortfall of Jude Liversage,s campaign so ... first time.      (Photo: http://photos.prnewswire.com/prnh/20150803/254228 ... The Selective Dorsal Rhizotomy (SDR) procedure reduced ... out his wish to kick a ball around like ...
(Date:8/3/2015)... Medical, Inc. (Nasdaq: AEMD ), the pioneer in ... announced that it will host its First Quarter Fiscal ... 13, 2015 at 4:30 p.m. Eastern Time. ... fiscal 2016 first quarter results.  A recorded version of ... the call at the Investor Relations portion of the ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... TLD5000 diaphragm vacuum pumps to its comprehensive line of analytical laboratory equipment. With ... valves, these versatile pumps provide a chemically resistant and maintenance-free solution for a ...
(Date:7/30/2015)... Marshall, MN (PRWEB) , ... July 31, 2015 , ... ... Ralco Enrichment Center at the Lyon County Fair to be held August 5-9 in ... more about where their meals come from and how agriculture impacts their daily lives. ...
Breaking Biology Technology:Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2Sterlitech Launches New Line of Vacuum Pumps 2Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2
... Facility, NEW YORK, Oct. 27 NeoStem, Inc. ... pre-disease collection,processing and long-term storage of adult stem cells ... on a private placement financing,in the amount of $250,000. ... stem cell collection network in the New York City ...
... Nile Therapeutics,Inc., (Nasdaq: NLTX ), announced today ... 7th Annual BIO Investor Forum on Thursday,October 30th, at ... Francisco., Mr. Strumph will provide an overview of ... interim data from Nile,s Phase 2a,study for its lead ...
... BURR RIDGE, Ill., Oct. 27 GSI ... company specializing in,printed electronics; sensors, electrodes, electroluminescent ... with NTERA, Inc. for,flexible printed display technologies. ... the NanoChromics(TM) technology has now been produced ...
Cached Biology Technology:NeoStem Secures $250,000 in an Above Market Financing and Expands Its Relationship With New England Cryogenic Center, Inc. 2NeoStem Secures $250,000 in an Above Market Financing and Expands Its Relationship With New England Cryogenic Center, Inc. 3Nile Therapeutics to Present at the 7th Annual BIO Investor Forum 2Electrochromic Display Technology Announcement 2
(Date:7/31/2015)... de 2015 BGI llevará a cabo la 10ª ... al 25 de octubre de 2015, en ... su décimo aniversario este año. Desde su inauguración en ... reuniones anuales más influyentes del mundo en los campos ... científicas más dinámicas, entusiastas y amenas. ICG-10 ...
(Date:7/31/2015)... 31, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market and creator of ... provisional patent 62/198989 for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT ... method to advance crypto-currencies such as Bitcoin into the ... uniform way to manage all payments.  ...
(Date:7/23/2015)... 23, 2015 Aware, Inc. (NASDAQ: AWRE ), ... financial results for its second quarter ended June 30, 2015.  ... was $4.5 million, a decrease of 33% compared to $6.8 ... the second quarter of 2015 was $0.3 million, or $0.01 ... per diluted share, in the same period a year ago.  ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... traced the origin of Plasmodium vivax , the second-worst ... published this week in Nature Communications . Until recently, ... were found only in Asian macaques, leading researchers to believe ... The study, led by researchers from the Perelman School of ...
... DNA sequencing technologies have enormous potential for the ... these new technologies, researchers are able to greatly ... key to applications including plant breeding and physiology. ... (or phylogenetic) relationships among different plant species have ...
... a spectrum of signals from hormones within a plant. ... in the roots of plants, and their journey to ... plant development. Though these phytohormones have been identified in ... within plants was previously poorly understood. Now, a ...
Cached Biology News:The parasite that escaped out of Africa 2The parasite that escaped out of Africa 3The parasite that escaped out of Africa 4Sequencing hundreds of nuclear genes in the sunflower family now possible 2Sequencing hundreds of nuclear genes in the sunflower family now possible 3Roots to shoots: Hormone transport in plants deciphered 2
... As research demands continue to grow, the ... spectral information has become necessary, especially when ... colors. The innovative C1si Confocal Microscope System ... and spectral capability not available in conventional ...
... is described by end-users to be "a ... fundamentals of light microscopy and electronic imaging. ... it does not require much space and ... lab environment. The DM-BA300 combines Motic's own ...
... for individual and parallel agitation control ,Single ... DASGIP vessels, featuring range of stirring speeds ... 16 overhead drives can be operated as ... and cellferm-pro® for microbiology and cell culture. ...
... Life Science LAS-3000 imaging system combines ... simplified user interface, providing significantly improved ... of modularities. The system is especially ... perfect standard system for Western blotting ...
Biology Products: