Navigation Links
Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS
Date:2/3/2009

Therapeutic Approach Provides HIV-Resistant Immune Cells

RICHMOND, Calif., Feb. 3 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that its collaborators at the University of Pennsylvania have opened a Phase 1 clinical trial to evaluate SB-728-T for the treatment of HIV/AIDS.

Based on Sangamo's zinc finger DNA-binding protein nuclease (ZFN) technology, SB-728-T has been shown in an animal model of HIV infection to lead to an increase in CD4+ T-cell counts, a reduction in viral load and expansion of CCR5-modified T-cells, suggesting resistance to HIV.

"This is the first time that we have had the ability to make a patient's T-cells permanently resistant to infection by CCR5-specific strains of HIV and we are very excited to begin a clinical trial of this novel ZFN-based therapy," said Carl June, M.D., Director of Translational Research at the Abramson Family Cancer Research Institute at the University of Pennsylvania School of Medicine. "The ability to protect immune cells from infection with HIV and the expansion of CCR5-modified T-cells has the potential to provide long-term control of both the virus itself and eventually the opportunistic infections characteristic of AIDS."

CCR5 is a co-receptor that enables HIV to enter and infect cells of the immune system. About ten years ago, it was observed that individuals carrying a natural mutation of their CCR5 gene, CCR5-delta32, were highly resistant to infection by HIV. These individuals, lacking a functional CCR5 (approximately 1-2% of the general population), are immunologically "normal". A variety of small molecule and antibody antagonists of CCR5 binding have been tested and developed as potential therapeutic agents for the treatment of HIV infection. In addition, there is a recent report
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Sangamo BioSciences Announces Fourth Quarter and Year-End 2008 Conference Call and Webcast
2. Sigma-Aldrich and Sangamo BioSciences Announce the Achievement of Key Throughput Milestone in Research Reagents Agreement
3. Sangamo BioSciences to Present at the 27th Annual J.P. Morgan Healthcare Conference
4. Sangamo BioSciences to Webcast Annual Investor and Analyst Briefing and Presentation at Piper Jaffray Health Care Conference
5. Sangamo BioSciences Appoints Paul Cleveland to Its Board of Directors and Chair of Audit Committee
6. Sangamo BioSciences Announces Results From Diabetic Neuropathy Clinical Trial SB-509-601
7. Sangamo BioSciences Reports Third Quarter 2008 Financial Results
8. Sangamo BioSciences Presents Data at ICAAC Demonstrating In Vivo Protection Against HIV Infection by CCR5-ZFN Therapeutic
9. Sangamo BioSciences Announces Third Quarter Conference Call and Webcast
10. Sangamo BioSciences to Present at Two Upcoming Investor Conferences
11. Sangamo BioSciences to Present at the UBS Global Life Sciences Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... January 15, 2014 Look inside the ... items for the lab, from fluid handling to instruments ... to ship when you order. , Preferred Solutions ... , from the L/S® model for precise flow control ...
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... erect as many as five more buildings on its new ... well beyond its existing base of 2,500 employees, according to ... said the company anticipates adding 1,500 more individual offices, about ... addition, there remains plenty of room on the 380-acre Verona ...
... As we saw in the last article, 2006 was a good year ... We also saw that it was a mixed bag for the large-cap ... for these much more solid companies, then how was it for the ... look, the chart below is a reminder of the overall key market ...
... Wis. - A new $140 million biomedical research ... to executives of the Medical College of Wisconsin ... , ,With Gov. Jim Doyle and Milwaukee ... Medical College and the Children's Research Institute ...
Cached Biology Technology:Epic Systems will build well beyond current staff size 2A Midwest small-cap, life-science surprise package 2A Midwest small-cap, life-science surprise package 3A Midwest small-cap, life-science surprise package 4A Midwest small-cap, life-science surprise package 5Medical College dedicates $140M research facility 2
(Date:4/16/2014)... you cannot lift your upper eyelid. You walk through life with ... they are rolled down in the eye socket. Obviously, such a ... their head. In order to correct this condition, one would need ... the April 16 print issue of the journal Neuron , ...
(Date:4/16/2014)... from the north-central U.S. and beyond will convene in ... science, expand on existing science, and explore the unique ... special emphasis on applied geology, paleontology, and mid-continent geology. ... Thursday by Dr. Kirk Johnson, Sant Director of the ...
(Date:4/16/2014)... , , Everything we do all of our movements, thoughts ... one another, and recent studies have suggested that some of ... known as astrocytes may be listening in on, or even ... study suggests that astrocytes might only be tuning in part ...
Breaking Biology News(10 mins):Researchers track down cause of eye mobility disorder 2Walking with mammoths and exploring mid-continental geology 2Walking with mammoths and exploring mid-continental geology 3Walking with mammoths and exploring mid-continental geology 4Eavesdropping on brain cell chatter 2Eavesdropping on brain cell chatter 3
... YORK , Dec. 3, 2013 Usernames and passwords ... public domains from unwarranted access. Yet, identity theft and corporate ... can be easily spoofed. Today, biometrics veteran Hector Hoyos ... aims to address and solve the issues of secure identity ...
... to the Arctic, as part of the Catlin Arctic Survey, ... just beneath the ocean surface are likely to battle for ... that copepods that move large distances, migrating vertically across a ... surviving. The increasing level of carbon dioxide in ...
... Arts and Sciences has developed a system of techniques ... a protected marine mammal habitat. The techniques are the ... Bulletin , focusing on the bottlenose dolphin population in ... in the Department of Biology, co-authored the article with ...
Cached Biology News:Hoyos Labs, a Digital Infrastructure Security Company, Launches; Rethinks How We Authenticate and Secure Identity 2Hoyos Labs, a Digital Infrastructure Security Company, Launches; Rethinks How We Authenticate and Secure Identity 3Arctic study shows key marine food web species at risk from increasing CO2 2SU biologist develops method for monitoring shipping noise in dolphin habitat 2
... HT is taking automated patch clamping to a ... ability to generate thousands of high quality data ... paradigms in ion channel drug discovery and safety ... quality afforded by conventional patch clamping can now ...
... mouse embryonic stem cells to dopaminergic neurons. ... where they are mainly located in the ... the retrorubral field. These dopaminergic (DA) neurons ... ( e.g.projections to the caudate nucleus, putamen ...
... RNA aptamer screening and binding optimization and ... microfluidic on-chip synthesis platform. Thousands of customer ... and LC Sciences can provide assistance with ... as part of our comprehensive DNA/RNA Aptamer ...
... synthetic peptide whose sequence is from the C-terminal end of the mouse ... from amino acids 429 to 448 of RAR*. The sequence of ... V - S - P - S - S - V - ... Q - S - P - L - L - Q ...
Biology Products: