Sangamo BioSciences Announces ZFP Therapeutic Data From Nerve Regeneration Program at Society for Neuroscien...( Statistically Significant Improvemen...)

Statistically Significant Improvements in Function and Tissue Preservation

with ZFP TF Treatment in Spinal Cord Injury Model

SAN DIEGO, Nov. 7 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today the presentation of preclinical data from its ZFP Therapeutic(TM) program in nerve regeneration at Neuroscience 2007, the 37th Annual Meeting of the Society for Neuroscience. A statistically significant effect on both recovery of hind-limb function and spinal cord tissue preservation was demonstrated in a severe model of spinal cord injury (SCI) following treatment at the time of injury with a zinc finger DNA-binding protein activator of vascular endothelial growth factor (VEGF ZFP TF).

"We are excited by the statistically significant improvements in measures of both nerve health and, more importantly, nerve function after treatment with our VEGF ZFP TF," said Dale Ando, M.D. Sangamo's vice president of therapeutic development and chief medical officer. "Data generated in these studies are consistent with other data from a variety of models that suggest that our ZFP TF activator of VEGF expression has regenerative effects on nerves and increases the density of blood vessels in and around the treated tissue.

We believe that these effects will prove therapeutically important in conditions that involve nerve damage including diabetic neuropathy, ALS, stroke and traumatic injuries to the brain, spinal cord and other nerves. We are very pleased to collaborate with Dr. Michael Fehlings, senior author of this study, who is world-renown for his work on SCI and has significant clinical trial experience in this area."

Sangamo is currently developing SB-509, a plasmid fo
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