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Sangamo BioSciences Announces Results From Diabetic Neuropathy Clinical Trial SB-509-601
Date:11/10/2008

a in several animal models of angiogenesis and nerve injury. We also have impressive data from our prior Phase 1 clinical study, SB-509-401, with a single treatment in the same patient population. In addition, we have encouraging positive interim data in our SB-509-701A study in which we are assessing recovery of nerve conduction velocity (NCV) in subjects with moderate to severe DN after two treatments with SB-509. Recovery of NCV in this more severe population that presents with "blocked" nerves or nerves with unmeasurable NCVs provides a binary outcome. The SB-509-701A trial is nearly complete and we expect to have more data from this study in the first quarter of 2009."

"The results from the SB-509-601 study are certainly unexpected," stated Edward Lanphier, Sangamo's president and CEO. "The data that we obtained on measures of nerve health and function are quite different than what we observed in our Phase 1b study. However, the 601 trial is only one part of our broad clinical development program to evaluate SB-509 which we will continue to prosecute. Based on our positive Phase 1b clinical data and encouraging interim data from our Phase 2 repeat-dosing study (SB-509-701A) in subjects with moderate to severe DN, we continue to have a high degree of confidence in this drug."

Conference Call

Sangamo will host a conference call today, November 10, 2008 at 5:00 p.m. ET, which will be open to the public. The call will also be webcast live and can be accessed via a link on the Sangamo BioSciences website in the Investor Relations section under "Events and Presentations" http://investor.sangamo.com/events.cfm . The webcast replay will also be available for two weeks after the call. During the conference call, the company will review the data presented today.

The conference call dial-in numbers are 888-690-2875 for domestic callers and 913-981-5543 for international callers.
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SOURCE Sangamo BioSciences, Inc.
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