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Sangamo BioSciences Announces Presentation of Phase 1 Data of ZFP Therapeutic at International Society for Cellular Therapy (ISCT) Meeting
Date:5/19/2008

oid Receptor Allow

IL-13 Zetakine Transgenic CTLs to Kill Glioblastoma Cells in vivo in

the Presence of Immunosuppressing Glucocorticoids" Philip Gregory, D.

Phil., Vice President, Research, Sangamo BioSciences, Inc.

-- Monday, May 19:

-- Workshop: "Emerging Technologies" Bruce Levine, Ph.D., Department

of Pathology and Laboratory Medicine, University of Pennsylvania

School of Medicine.

-- Poster Session: "Controlling HIV in vivo - Establishment of HIV

Resistant CD4 T Cells by Engineered Zinc Finger Protein

Nucleases."

About Sangamo

Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therapeutic(TM) development program is currently in Phase 2 clinical trials for evaluation of safety and clinical effect in patients with diabetic neuropathy. Phase 1 clinical trials are ongoing to evaluate a ZFP Therapeutic for peripheral artery disease. Other therapeutic development programs are focused on cancer and HIV/AIDS, neuropathic pain, nerve regeneration, Parkinson's disease and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF)(TM) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases (ZFN)(TM) for gene modification. Sangamo has established strategic partnerships with companies outside of the human therapeutic space including Dow AgroSciences, Sigma-Aldrich Corporation and several companies applying its ZFP Technology to enhance the production of protein pharmaceuticals. For more information about Sangamo, visit the company's web site at '/>"/>

SOURCE Sangamo BioSciences, Inc.
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