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Sangamo BioSciences Announces Presentation of New Data from ZFP Therapeutic® Program in Hemophilia B at American Society for Hematology Meeting
Date:12/13/2011

r hemophilia B program into preclinical studies in a large animal model of the disease," stated Edward Lanphier, Sangamo's president and chief executive officer. "As these presentations demonstrate, our ZFN gene-editing platform has broad applicability in that it can be applied to any disease-relevant gene enabling permanent gene modification and has the potential to provide a valuable therapeutic approach to a variety of unmet medical needs."

* Nature. 2011 Jun 26;475 (7355):217-21. doi: 10.1038/nature10177. "In vivo genome editing restores haemostasis in a mouse model of haemophilia".

About Sangamo

Sangamo BioSciences, Inc. is focused on research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. Sangamo has a Phase 1 / 2 clinical trial and two ongoing Phase 1 clinical trials to evaluate the safety and efficacy of a treatment for HIV/AIDS as well as a Phase 1 trial to evaluate a treatment for recurrent glioblastoma multiforme.  Other therapeutic programs are focused on Parkinson's disease, monogenic diseases and neuropathic pain.  Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs).  By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TFs) that can control gene expression and, consequently, cell function.  Sangamo is also developing sequence-specific ZFP Nucleases (ZFNs) for gene modification.  Sangamo has established strategic partnerships with companies in non-therapeutic applications of its technology including Dow AgroSciences and Sigma-Aldrich Corporation. For more information about Sangamo, visit the company's website at www.sangamo.com.

ZFP Therapeutic® is a registered trademark of Sangamo BioSciences, Inc.

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