Navigation Links
Safer nanoparticles spotlight tumors, deliver drugs
Date:2/22/2009

Small is promising when it comes to illuminating tiny tumors or precisely delivering drugs, but many worry about the safety of nano-scale materials. Now a team of scientists has created miniscule flakes of silicon that glow brightly, last long enough to slowly release cancer drugs, then break down into harmless by-products.

"It is the first luminescent nanoparticle that was purposely designed to minimize toxic side effects," said Michael Sailor, a chemistry professor at the University of California, San Diego who led the study.

Many nanoparticles tested in research labs are too poisonous for use in humans.

"This new design meets a growing need for non-toxic alternatives that have a chance to make it into the clinic to treat human patients," Sailor said.

The particles inherently glow, a useful property that is most commonly achieved by including toxic organic chemicals or tiny structures called quantum dots, which can leave potentially harmful heavy metals in their wake.

When the researchers tested their safer nanoparticles in mice, they saw tumors glow for several hours, then dim as the particles broke down. Levels dropped noticeably in a week and were undetectable after four weeks, they report in Nature Materials February 22.

This is the first sudy to image tumors and organs using biodegradable silicon nanoparticles in live animals, the authors say.

The particles begin as thin wafers made porous with an electrical current then smashed to bits with ultrasound. Additional treatment alters the physical structure of the flakes to make them glow red when illuminated with ultraviolet light.

Luminescent particles can reveal tumors too tiny to detect by other means or allow a surgeon to be sure all of a cancerous growth has been removed.

These nanoparticles could also help deliver drugs safely, the researchers report. The cancer drug doxorubicin will stick to the pores and slowly escape as the silicon dissolves.

"The goal is to use the nanoparticles to chaperone the drug directly to the tumor, to release it into the tumor rather than other parts of the body," Sailor said.

Targeted delivery would allow doctors to use smaller doses of the drug. At doses high enough to be effective, when delivered to the whole body, doxorubicin often has toxic side effects.

At about 100 nanometers, these particles are bigger than many designed to deliver drugs, which can be just a few nanometers across a thousand times smaller than the diameter of a human hair.

Their larger size contributes to both their effectiveness and their safety. Large particles can hold more of a drug. Yet they self-destruct, and the remnants can be filtered away by the kidneys.

Close examination of vulnerable organs like liver, spleen and kidney, which help to remove toxins, revealed no lasting changes in mice treated with the new nanoparticles.


'/>"/>

Contact: Michael Sailor
msailor@ucsd.edu
University of California - San Diego
Source:Eurekalert  

Related biology technology :

1. Developing a Safer and More Effective Way to Deliver Rabies Antibodies
2. BioLife Solutions Joins Prestigious Biomedical Excellence for Safer Transfusion Collaborative
3. ICU Medical Inc. and Health Robotics Announce Compatibility of CytoCare(TM) Robot and CLAVE(R) Needle-Free Connector to Enable Safer Hazardous Drug Handling
4. Safer, easier system for remote explosive detection
5. Using supercomputers to make safer nuclear reactors
6. Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide
7. Nanoparticles double their chances of getting into sticky situations
8. Enhancing solar cells with nanoparticles
9. Surface plasmon resonances of metal nanoparticles in array can have narrower spectral widths
10. Engineering nanoparticles for maximum strength
11. NC State engineers discover nanoparticles can break on through
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Safer nanoparticles spotlight tumors, deliver drugs
(Date:2/9/2016)... CA (PRWEB) , ... February 08, 2016 , ... ... and multilingual testing services, announced today the launch of its revamped and improved ... of scalable language service solutions, the redesigned website will better communicate how the ...
(Date:2/9/2016)... NJ (PRWEB) , ... February 09, 2016 , ... ... Dorman, former Vice President for Public Policy for the National Organization for Rare ... patient advocacy groups to ensure their voices are heard throughout the drug regulatory ...
(Date:2/9/2016)... 2016 BERG, a biopharmaceutical company uncovering ... has announced the appointment of Jason Haddock ... Officer. Haddock brings to BERG over 20 years ... in senior financial functions at pharmaceutical companies, as ... management. Niven R. Narain , ...
(Date:2/8/2016)... 8, 2016 --> ... an innovation-driven oncology company developing next generation cancer ... today announced that chairman emeritus of Tata Sons ... the company as part of the first close ... investors Navam Capital and Aarin Capital. ...
Breaking Biology Technology:
(Date:2/4/2016)... -- The field of Human Microbiome research and ... hubs of the biotechnology industry. While the Human ... human microbiota, have garnered a lot of attention ... has literally exploded in terms of both basic ... on biomedical aspects of research, development, and commercial ...
(Date:2/2/2016)... , Feb. 2, 2016  BioMEMS ... are primarily focused on medical screening and ... point-of-care parameters. Wearable devices that facilitate and ... freedom of movement are being bolstered through ... human biomedical signal acquisition coupled with wireless ...
(Date:2/2/2016)... , Feb. 2, 2016  Based on ... Frost & Sullivan recognizes US-based Intelligent Retinal Imaging ... & Sullivan Award for New Product Innovation. IRIS, ... North America , is poised ... rapidly growing diabetic retinopathy market. The IRIS technology ...
Breaking Biology News(10 mins):