Navigation Links
Safer nanoparticles spotlight tumors, deliver drugs
Date:2/22/2009

Small is promising when it comes to illuminating tiny tumors or precisely delivering drugs, but many worry about the safety of nano-scale materials. Now a team of scientists has created miniscule flakes of silicon that glow brightly, last long enough to slowly release cancer drugs, then break down into harmless by-products.

"It is the first luminescent nanoparticle that was purposely designed to minimize toxic side effects," said Michael Sailor, a chemistry professor at the University of California, San Diego who led the study.

Many nanoparticles tested in research labs are too poisonous for use in humans.

"This new design meets a growing need for non-toxic alternatives that have a chance to make it into the clinic to treat human patients," Sailor said.

The particles inherently glow, a useful property that is most commonly achieved by including toxic organic chemicals or tiny structures called quantum dots, which can leave potentially harmful heavy metals in their wake.

When the researchers tested their safer nanoparticles in mice, they saw tumors glow for several hours, then dim as the particles broke down. Levels dropped noticeably in a week and were undetectable after four weeks, they report in Nature Materials February 22.

This is the first sudy to image tumors and organs using biodegradable silicon nanoparticles in live animals, the authors say.

The particles begin as thin wafers made porous with an electrical current then smashed to bits with ultrasound. Additional treatment alters the physical structure of the flakes to make them glow red when illuminated with ultraviolet light.

Luminescent particles can reveal tumors too tiny to detect by other means or allow a surgeon to be sure all of a cancerous growth has been removed.

These nanoparticles could also help deliver drugs safely, the researchers report. The cancer drug doxorubicin will stick to the pores and
'/>"/>

Contact: Michael Sailor
msailor@ucsd.edu
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Developing a Safer and More Effective Way to Deliver Rabies Antibodies
2. BioLife Solutions Joins Prestigious Biomedical Excellence for Safer Transfusion Collaborative
3. ICU Medical Inc. and Health Robotics Announce Compatibility of CytoCare(TM) Robot and CLAVE(R) Needle-Free Connector to Enable Safer Hazardous Drug Handling
4. Safer, easier system for remote explosive detection
5. Using supercomputers to make safer nuclear reactors
6. Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide
7. Nanoparticles double their chances of getting into sticky situations
8. Enhancing solar cells with nanoparticles
9. Surface plasmon resonances of metal nanoparticles in array can have narrower spectral widths
10. Engineering nanoparticles for maximum strength
11. NC State engineers discover nanoparticles can break on through
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Safer nanoparticles spotlight tumors, deliver drugs
(Date:7/25/2014)... A new study by researchers from the University ... tiny nanosystems function, unlocking the potential to create ... study, which has been published in the prestigious ... a novel laser technique to examine in rich ... a small cluster containing an acetylene molecule and ...
(Date:7/25/2014)... The Conferee Networking committee is pleased ... Networking. These two-hour sessions provide a unique networking opportunity ... problems, discuss new techniques, or brainstorm new ideas in ... topic for consideration is August 31, 2014, and instructions ... Networking committee will review the topics, and status notifications ...
(Date:7/25/2014)... At the request of the AMA, ... extension for the public comment period (Docket No. FAA-2014-0396) ... Aircraft established by Congress as part of the FAA ... establishes the new deadline for comments as September 23, ... notice published in the Federal Register on July 25, ...
(Date:7/24/2014)... Gain recognition for leadership and ... the biotech industry. Nominations are now being accepted ... you by the Bio Supply Management Alliance ... management professionals for the past 7 years. , ... Biotech industry – Manufacturers, Service Providers, Material Suppliers, ...
Breaking Biology Technology:Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2FAA Grants Comment Extension at the Request of AMA 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3
... WALTHAM, Mass., Dec. 3 Thermo Fisher,Scientific Inc. (NYSE: ... today,announced that the China Doping Control Center (CDCC) has ... instrumentation and software for,the testing of athletes at the ... by the Chinese government and the International Olympic,Committee (IOC) ...
... STUDIO CITY, Calif., Dec. 3 Signalife, Inc.,(Amex: ... the XIII World Congress on,Cardiac Pacing and Electrophysiology ... At the Congress, Dr. Muricio Arruda, who has ... the,Electrophysiology Laboratories of the Cleveland Clinic Heart Center, ...
... IDenta Corp.,(OTC: IDTA.PK - News) announced today that ... test kit that will detect the presence of lead ... recent outbreak of lead,contamination in products produced in China ... yet unnamed, the new IDenta lead detector will be,targeted ...
Cached Biology Technology:Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 2Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 3Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 4Signalife Presence at XIII World Congress on Cardiac Pacing and Electrophysiology 2Signalife Presence at XIII World Congress on Cardiac Pacing and Electrophysiology 3International Substance Detection Firm IDenta To Release New Lead Test Kit - Rash Of Toy Incidents Leads Company To Enter New Marketplace 2International Substance Detection Firm IDenta To Release New Lead Test Kit - Rash Of Toy Incidents Leads Company To Enter New Marketplace 3
(Date:7/28/2014)... Yale School of Medicine have pinpointed a mechanism in part ... in the blood, linking it to both type 1 and ... 28 issue of Proceedings of the National Academies of ... enzyme located in a part of the hypothalamus known ... in motion that control glucose levels in the blood," said ...
(Date:7/28/2014)... study of juvenile rat brain cells suggests that the ... connections between brain cells are temporary. , The study, ... PLOS ONE , was conducted by biologists at the ... College in New York in response to concerns, arising ... that exposing children to general anesthetics may increase their ...
(Date:7/28/2014)... genome of Solanum pennellii , a wild relative ... international group of researchers including the labs headed by ... Davis Department of Plant Biology. The new genome information ... The work, published July 27 in the journal ... colleagues at Aachen University in Germany. The UC Davis ...
Breaking Biology News(10 mins):Glucose 'control switch' in the brain key to both types of diabetes 2Study suggests disruptive effects of anesthesia on brain cell connections are temporary 2Study suggests disruptive effects of anesthesia on brain cell connections are temporary 3
... what you know often comes at the price of learning ... easy for many, but not for those with conditions such ... simple routines. Using brain scans in monkeys, Duke ... monkeys will switch from exploiting a known resource to exploring ...
... Taylor Chair of Chemistry Barry Dellinger was recently awarded a ... Health Sciences, or NIEHS, to support a Superfund Research Center ... health. It is the only center ever awarded by this ... school of public health. "This grant is the result of ...
... semi-decayed vegetation matter, has been used by commercial growers ... century. Peat is added to potting soil to help ... for peat grew, acres of peat bogs were being ... of extracting peat from wetlands are mounting. And as ...
Cached Biology News:Monkey brains signal the desire to explore 2LSU receives $3.6 million to fund center studying hazardous waste cleanup and health impacts 2For peat's sake: Alternative growing media 2
Recognizes the 41 and 43 kDa G-proteins present in liver plasma membranes and Gq/11alpha expressed in the Sf9 insect cell expression system. Negative for recombinant G(I)alpha subtypes....
Pancreatic Cell Cryopreservation Medium (2X) is intended for the cryopreservation of LT2 Immortalized Pancreatic Mesenchymal Cells (SCR013) and VIT1 Primary Pancreatic Mesenchymal Cells (SCR014)....
LAB/Probe Mouse-Rabbit DAB Kit...
Mouse monoclonal [SH-A1] to S100 alpha ( Abpromise for all tested applications). entrezGeneID: 6271 SwissProtID: P23297...
Biology Products: