Navigation Links
Safer nanoparticles spotlight tumors, deliver drugs
Date:2/22/2009

Small is promising when it comes to illuminating tiny tumors or precisely delivering drugs, but many worry about the safety of nano-scale materials. Now a team of scientists has created miniscule flakes of silicon that glow brightly, last long enough to slowly release cancer drugs, then break down into harmless by-products.

"It is the first luminescent nanoparticle that was purposely designed to minimize toxic side effects," said Michael Sailor, a chemistry professor at the University of California, San Diego who led the study.

Many nanoparticles tested in research labs are too poisonous for use in humans.

"This new design meets a growing need for non-toxic alternatives that have a chance to make it into the clinic to treat human patients," Sailor said.

The particles inherently glow, a useful property that is most commonly achieved by including toxic organic chemicals or tiny structures called quantum dots, which can leave potentially harmful heavy metals in their wake.

When the researchers tested their safer nanoparticles in mice, they saw tumors glow for several hours, then dim as the particles broke down. Levels dropped noticeably in a week and were undetectable after four weeks, they report in Nature Materials February 22.

This is the first sudy to image tumors and organs using biodegradable silicon nanoparticles in live animals, the authors say.

The particles begin as thin wafers made porous with an electrical current then smashed to bits with ultrasound. Additional treatment alters the physical structure of the flakes to make them glow red when illuminated with ultraviolet light.

Luminescent particles can reveal tumors too tiny to detect by other means or allow a surgeon to be sure all of a cancerous growth has been removed.

These nanoparticles could also help deliver drugs safely, the researchers report. The cancer drug doxorubicin will stick to the pores and slowly escape as the silicon dissolves.

"The goal is to use the nanoparticles to chaperone the drug directly to the tumor, to release it into the tumor rather than other parts of the body," Sailor said.

Targeted delivery would allow doctors to use smaller doses of the drug. At doses high enough to be effective, when delivered to the whole body, doxorubicin often has toxic side effects.

At about 100 nanometers, these particles are bigger than many designed to deliver drugs, which can be just a few nanometers across a thousand times smaller than the diameter of a human hair.

Their larger size contributes to both their effectiveness and their safety. Large particles can hold more of a drug. Yet they self-destruct, and the remnants can be filtered away by the kidneys.

Close examination of vulnerable organs like liver, spleen and kidney, which help to remove toxins, revealed no lasting changes in mice treated with the new nanoparticles.


'/>"/>

Contact: Michael Sailor
msailor@ucsd.edu
University of California - San Diego
Source:Eurekalert  

Related biology technology :

1. Developing a Safer and More Effective Way to Deliver Rabies Antibodies
2. BioLife Solutions Joins Prestigious Biomedical Excellence for Safer Transfusion Collaborative
3. ICU Medical Inc. and Health Robotics Announce Compatibility of CytoCare(TM) Robot and CLAVE(R) Needle-Free Connector to Enable Safer Hazardous Drug Handling
4. Safer, easier system for remote explosive detection
5. Using supercomputers to make safer nuclear reactors
6. Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide
7. Nanoparticles double their chances of getting into sticky situations
8. Enhancing solar cells with nanoparticles
9. Surface plasmon resonances of metal nanoparticles in array can have narrower spectral widths
10. Engineering nanoparticles for maximum strength
11. NC State engineers discover nanoparticles can break on through
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Safer nanoparticles spotlight tumors, deliver drugs
(Date:1/19/2017)... 19, 2017 AquaBounty Technologies, Inc. (AIM: ABTU; ... in aquaculture and a majority-owned subsidiary of Intrexon Corporation ... completed the listing of its common shares on the ... Intrexon. "AquaBounty,s listing on NASDAQ represents an ... exposure to the U.S. markets as we advance plans ...
(Date:1/19/2017)... ... January 19, 2017 , ... FireflySci Inc. is a go-getter type of ... growth is accounted to two main factors. The first is the amazing customer ... vendors supplying FireflySci products all around the world. , 2016 was a tremendous sales ...
(Date:1/19/2017)... BETHESDA, Md. , Jan. 18, 2017  Northwest ... company developing DCVax® personalized immune therapies for operable and ... Marnix Bosch , Chief Technical Officer of NW Bio, ... Thursday, January 19, 2017, at the Hyatt Regency Hotel ... Dr. Bosch will chair the session entitled "New Therapeutic ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... device-to-computer interconnect using USB or PCI Express, announced the ZEM5310 USB 3.0 FPGA ... FPGA into a compact business-card sized form factor suitable for prototyping, testing, and ...
Breaking Biology Technology:
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
(Date:12/15/2016)... 2016  There is much more to innovative access ... engine. Continental will demonstrate the intelligence of today,s solutions ... . Through the combination of the keyless entry and ... elements, the international technology company is opening up new ... "The integration of biometric elements brings our ...
(Date:12/8/2016)... Calif. , Dec. 8, 2016  Singulex, Inc., ... Molecule Counting technology, entered into a license and supply ... serving science. The agreement provides Singulex access to Thermo ... Europe is used to diagnose systemic ... United States to aid in assessing the ...
Breaking Biology News(10 mins):