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SYNTAX substudy shows positive outcomes for left main patients treated with TAXUS(R) Express(2)(R) Stent System
Date:5/19/2009

XUS Stent, the patency rate for the treated lesion was 92 percent. Restenosis was more common with distal lesions (90% patency) compared with non-distal lesions (98% patency). Reported in-stent late loss was low at 0.2 mm for non-distal lesions. The reported 15-month MACCE rate (all-cause death, stroke, myocardial infarction and revascularization) for the TAXUS Stent patients was 13 percent, driven primarily by a nine percent repeat revascularization rate.

For CABG patients, the overall obstruction/occlusion ratio at 15 months was 16 percent, with six percent of grafts obstructed in the range of (greater than or equal to)50% to (less than)100%, and 10 percent of grafts occluded 100%. On a per patient basis, the obstruction/occlusion ratio was 27 percent, with nine percent of patients having a graft obstructed in the (greater than or equal to)50% to (less than)100% range and 18 percent of patients having a graft occluded 100%. The reported MACCE rate for CABG patients at 15 months was nine percent.

"The data announced today from SYNTAX-LE MANS will offer important insights for doctors as they evaluate treatment options for challenging left main patients," said Keith Dawkins, M.D., Associate Chief Medical Officer of Boston Scientific. "We are encouraged by the high stent patency rate at 15 months, which increases our confidence in the application of PCI in this high-risk population. The results support previously announced outcomes with PCI and CABG in patients with left main disease."

The safety and effectiveness of the TAXUS Express(2) Stent System have not been established in patients with left main or three-vessel disease.

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SOURCE Angiotech Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
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