Navigation Links
SGX Pharmaceuticals Provides Update on SGX523 Clinical Trials
Date:3/27/2008

Company Presents Today at BioCentury Future Leaders Conference

SAN DIEGO, March 27 /PRNewswire-FirstCall/ -- SGX Pharmaceuticals (Nasdaq: SGXP) is providing an update today on the SGX523 clinical program.

In January 2008, the Company initiated two parallel, multi-center Phase 1 clinical trials of SGX523 in patients with solid tumor cancers. The first trial has been designed to examine twice daily, oral dosing on a continuous 28-day cycle and the second trial has been designed to examine interrupted dosing (a repeating 21 day cycle of 14 days on therapy followed by 7 days off).

In both trials, the Company observed dose limiting toxicity earlier than anticipated. The toxicity is of a nature that was not anticipated based on the preclinical profile of SGX523. The interrupted dosing trial started at a higher dose than the continuous dosing trial and no patients are currently receiving treatment on the interrupted dosing trial. In the continuous dosing trial, patients are continuing to be treated at a lower dose level, and the Company is evaluating the safety and efficacy of treatment at that dose level.

"From the initial clinical data, the profile of SGX523 appears to be different than the preclinical data would suggest," said Mike Grey, president and chief executive officer of SGX Pharmaceuticals. "On the continuous dosing trial, patients continue on study at the initial dose and we may explore whether alternative doses and schedules are safe and efficacious. We continue the preclinical development of the BCR-ABL inhibitor SGX393 and the second MET inhibitor SGX126. In addition, we are targeting the identification of two development candidates this year from our drug discovery programs to further enhance our pi
'/>"/>

SOURCE SGX Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Alseres Pharmaceuticals to Host 2007 Financial Results Conference Call
2. Millennium Biotechnologies, Inc. Signs Marketing and Distribution Agreement with Ferring Pharmaceuticals
3. Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data
4. XTL Biopharmaceuticals Signs $108 Million Deal for the Licensing of its Pre- Clinical Program in Hepatitis C to Presidio Pharmaceuticals
5. SGX Pharmaceuticals to Present at the BioCentury Future Leaders in the Biotech Industry Conference
6. Raptor Pharmaceuticals Corp. Enters Agreements to Advance Clinical Pipeline
7. LigoCyte Pharmaceuticals Finalizes Agreement for $28M Series C Financing Round
8. Jazz Pharmaceuticals, Inc. Announces Expansion of Senior Debt
9. Vion Pharmaceuticals to Host Conference Call to Discuss 2007 Fourth Quarter and Year-End Financial Results
10. MiddleBrook Pharmaceuticals to Present at Lehman Brothers Global Healthcare Conference
11. Cadence Pharmaceuticals to Present at the Cowen and Company 28th Annual Health Care Conference on March 20, 2008 in Boston
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... May 29, 2015 BerGenBio AS ... announces that an abstract on the latest data on ... the Axl receptor tyrosine kinase, and BGB10C9, an Axl ... been published in conjunction with the 2015 American Society ... Chicago , May 29 - June 2, 2015. ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 The Academy ... to thirteen high school graduates from across the nation. ... created to award qualified AMA Youth Members with scholarships ... the AMA Scholarship Program has awarded nearly $900,000 to ... by model aviation organizations and individuals, AMA member donations, ...
(Date:5/29/2015)... London, UK (PRWEB) May 29, 2015 ... Co., Ltd. (Chem-Report ) signed a partnership agreement ... is now authorised to distribute and sell research ... Assistant Manager at Partners Department, commented upon the ... creating reports on key petroleum and chemical markets ...
(Date:5/29/2015)... When a leading manufacturer of ... to design an industrial oven that ... being produced using a 3D-printing process, Gruenberg engineers ... gantry, heat-saving windows, and internal actuators and sensors ... pills to exact specifications. , To ensure the ...
Breaking Biology Technology:BGB324 and BGB10C9 Show Promise in Models of Pancreatic Cancer 2BGB324 and BGB10C9 Show Promise in Models of Pancreatic Cancer 3Academy of Model Aeronautics Awards $46,500 in Scholarships to College-Bound Model Aviation Pilots 2Market Publishers Ltd and Chem-Report Sign Partnership Agreement 2Market Publishers Ltd and Chem-Report Sign Partnership Agreement 3New industrial oven with “pill pushing” robotic gantry precisely removes excess moisture from 3D-printed pharmaceuticals 2
... Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field ... first half year of 2011. Highlights ... Glybera produces significant reduction in risk of pancreatitis in LPLD ... does not consider Glybera approvable at this time ...
... new discovery by Aalto University can have major impact ... detectors and drug delivery. In bulk size, many ... nanoparticle size, the same material can be compressed into ... was made by an international research group led by ...
... Questcor Pharmaceuticals, Inc. (NASDAQ: QCOR ) announced ... investor conferences in early September:   ... Hyatt in New York City.  Don M. Bailey, President ... overview of the Company on Wednesday, September 14, 2011 ...
Cached Biology Technology:Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 2Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 3Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 4Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 5Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 6Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 7Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 8Questcor Pharmaceuticals to Present at Upcoming Investor Conferences in September 2
(Date:5/27/2015)... 27, 2015   Codonics (codonics.com), ... and image documentation solutions and Omnicell ... automation solutions, is pleased to announce their ... Safe Label System® (SLS), an award-winning FDA ... the Omnicell Anesthesia Workstation, helps prevent medication ...
(Date:5/22/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... promotional pricing and making the Wocket generally available for $229 ... Head of Marketing said, "We,ve extended the opportunity to take ... May. To get your wocket at this special price, submit ... on June 1, you,ll receive a unique code that gives ...
(Date:5/21/2015)... 21, 2015 The Sync Project™ , ... for health, today announced a collaborative partnership with ... will center on collaboration on original research, joint course ... in the collaboration, The Sync Project and BerkleeICE are ... Medicine" in the 2015-2016 academic year.  ...
Breaking Biology News(10 mins):Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 2NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 3The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3
... (ZnO) particles with dimensions less than one-ten-millionth of a ... available sunscreen products, raising concerns about whether the particles ... To help answer these safety questions, an international ... a way to optically test the concentration of ZnO ...
... of two techniques promises to improve the efficiency and ... side effects says a new research report published in ... ( http://www.fasebj.org ). The report describes how scientists ... site-specific recombinases, or enzymes that facilitate the exchange of ...
... eat baked or broiled fish on a weekly basis ... risk of developing mild cognitive impairment (MCI) and Alzheimer,s ... annual meeting of the Radiological Society of North America ... a direct relationship between fish consumption, brain structure and ...
Cached Biology News:Scientists use laser imaging to assess safety of zinc oxide nanoparticles in sunscreen 2The newest of the new in gene therapy: 'Tag and target and exchange' 2Eating fish reduces risk of Alzheimer's disease 2
... by A300-183A maps to the ... human quaking homolog according to ... The epitope is not found ... 4, 6, 7 or 7B ...
Flotillin-2 (ESA) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 29, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
...
... [198C679.2.1] to Presenilin 2 Alzheimer's disease ... the disease carry mutations in the presenilin ... protein (APP). These disease-linked mutations result in ... amyloid-beta (main component of amyloid deposits found ...
Biology Products: