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SENOMYX ANNOUNCES INITIATION OF DEVELOPMENT ACTIVITIES FOR NEW SUCROSE ENHANCER
Date:7/29/2008

President, Chief Financial and Business Officer at the Company. "Senomyx is also planning to incorporate S6973 in additional product prototypes for evaluation by potential future collaborators. These prototypes are representative of product categories that utilize sucrose such as ice cream and other dairy products, sauces and toppings, and baked goods."

The development phase includes scale-up activities and safety studies to support regulatory filings for S6973 in the U.S. and elsewhere. Concurrent with its work with S6973, Senomyx is completing development activities with S2383, an enhancer of the high-intensity sweetener sucralose. S2383 enabled up to a 75% reduction of sucralose in simple product prototypes, yet maintained the same sweet intensity without any off-tastes. The Company anticipates that S2383 will receive GRAS (Generally Recognized As Safe) regulatory status in the U.S. by the end of 2008.

"We are excited to have achieved such important breakthroughs in our Sweet Enhancer Program," added Mark Zoller, Ph.D., Senomyx's Chief Scientific Officer and Executive Vice President of Discovery and Development. "Reducing sugar consumption is a priority for consumers who have dietary concerns, particularly those related to obesity and diabetes. The new sucrose and sucralose enhancers were discovered utilizing Senomyx's patented taste receptor technology, which we are now using to focus on the discovery of enhancers of fructose, another carbohydrate sweetener used in a wide range of consumer products."

About Senomyx, Inc. (http://www.senomyx.com)

Senomyx is a leading company using proprietary taste receptor technologies to discover and develop novel flavor ingredients in the savory, sweet, salt, bitter, and cooling areas. Senomyx has entered into product discovery and development collaborations with seven of the world's foremost food, beverage, and ingredient supply companies: Ajinomot
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