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SAPHRIS(R) (asenapine) Meets Primary Endpoint in Long-Term Extension Study in Patients With Predominant, Persistent Negative Symptoms of Schizophrenia
Date:7/24/2009

is, blood insulin increase, irritability, dry mouth and nausea.

About SAPHRIS

Schering-Plough acquired SAPHRIS in November 2007 through its acquisition of Organon BioSciences, which developed the psychotropic agent. In the United States, a New Drug Application (NDA) for SAPHRIS sublingual tablets is currently under review by the U.S. Food and Drug Administration (FDA) and includes data from a clinical trial program involving more than 3,000 patients in bipolar mania and schizophrenia trials. In Europe, a Marketing Authorization Application (MAA) for asenapine, under the brand name SYCREST(R), is currently under review by the European Medicines Agency (EMEA).

About schizophrenia

Schizophrenia is a chronic, disabling brain disorder characterized by hallucinations, delusions and disordered thinking (often termed positive symptoms), and cognitive deficits, as well as negative symptoms such as apathy, avolition, diminished social drive, poverty of speech or curbing of interest, which are frequent disabling symptoms. About 24 million people worldwide (or seven in every 1,000 adults in the population) have schizophrenia, including more than two million people in the United States and more than four million people in Europe.

About Schering-Plough

Schering-Plough is an innovation-driven, science-centered global health care company. Through its own biopharmaceutical research and collaborations with partners, Schering-Plough creates therapies that help save and improve lives around the world. The company applies its research-and-development platform to human prescription, animal health and consumer health care products. Schering-Plough's vision is to "Earn Trust, Every Day" with the doctors, patients, customers and other stakeholders served by its colleagues around the world. The company is based in Kenilworth, N.J., and its Web site is www.schering-plough.com.


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