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SAFC Biosciences(R) Defines Hydrolysate Components That Enhance Chinese Hamster Ovary (CHO) Cell Line Protein Production
Date:7/28/2009

ST. LOUIS, July 29 /PRNewswire-FirstCall/ -- SAFC Biosciences(R), a business segment within SAFC(R), a member of the Sigma-Aldrich Group (Nasdaq: SIAL), announced today that it has developed a new, chemically defined cell culture supplement based on the characterization of hydrolysate components proven to provide cell growth and protein production capabilities equivalent to traditional undefined hydrolysate raw materials. The introduction of EX-CELL(R) CD Hydrolysate Fusion marks the Company's continued focus on raw material characterization (http://www.safcbiosciences.com/ChemicallyDefinedComponents).

Scientists at SAFC Biosciences have determined that an ideal method for biopharmaceutical manufacturers to increase process consistency and reproducibility, while mimicking the productivity and quality profile results from their current hydrolysate-containing processes, is to fully characterize and define those components contained within them. As a result of these studies, EX-CELL CD Hydrolysate Fusion, a synthetically produced animal-component free, chemically defined alternative to undefined hydrolysates, has been created for use in CHO, NS0 and Sp2/0 biopharmaceutical production processes. The liquid version (Product No. 14700C) is formulated as a 20X concentrated supplement designed to have minimal pH and osmolality impact upon addition. For additional flexibility, a readily soluble dry powder version (Product No. 24700C) is also available.

EX-CELL CD Hydrolysate Fusion was developed utilizing Sigma-Aldrich's unique analytical capabilities and expert biological assay development knowledge. Thi
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SOURCE Sigma-Aldrich
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