Navigation Links
SAFC Biosciences(R) Defines Hydrolysate Components That Enhance Chinese Hamster Ovary (CHO) Cell Line Protein Production
Date:7/28/2009

ST. LOUIS, July 29 /PRNewswire-FirstCall/ -- SAFC Biosciences(R), a business segment within SAFC(R), a member of the Sigma-Aldrich Group (Nasdaq: SIAL), announced today that it has developed a new, chemically defined cell culture supplement based on the characterization of hydrolysate components proven to provide cell growth and protein production capabilities equivalent to traditional undefined hydrolysate raw materials. The introduction of EX-CELL(R) CD Hydrolysate Fusion marks the Company's continued focus on raw material characterization (http://www.safcbiosciences.com/ChemicallyDefinedComponents).

Scientists at SAFC Biosciences have determined that an ideal method for biopharmaceutical manufacturers to increase process consistency and reproducibility, while mimicking the productivity and quality profile results from their current hydrolysate-containing processes, is to fully characterize and define those components contained within them. As a result of these studies, EX-CELL CD Hydrolysate Fusion, a synthetically produced animal-component free, chemically defined alternative to undefined hydrolysates, has been created for use in CHO, NS0 and Sp2/0 biopharmaceutical production processes. The liquid version (Product No. 14700C) is formulated as a 20X concentrated supplement designed to have minimal pH and osmolality impact upon addition. For additional flexibility, a readily soluble dry powder version (Product No. 24700C) is also available.

EX-CELL CD Hydrolysate Fusion was developed utilizing Sigma-Aldrich's unique analytical capabilities and expert biological assay development knowledge. This partnership of technology and expertise enabled SAFC Biosciences to develop the first known chemically defined hydrolysate replacement. Matt Caple, SAFC Biosciences Director of Cell Sciences and Development, states: "The capacity for hydrolysates to exert substantial positive impact on cell growth and/or protein production is well documented. But, the undefined and variable nature of these components still inhibits the pursuit of highly controlled and defined pharmaceutical production processes. EX-CELL CD Hydrolysate Fusion resolves this challenge by delivering a fully defined raw material."

Bruce Lehr, SAFC Biosciences Director of Marketing, states: "Raw material understanding and characterization is a leading concern for biopharmaceutical manufacturers interested in mitigating risk. They desire to mitigate supply risk and production variability stemming from the use of undefined or adulterated raw materials in their process. Control of this variable enables manufacturers to design quality into their process instead of testing for it at the end. EX-CELL CD Hydrolysate Fusion is proof that greater raw material definition is possible through advanced analytical techniques."

Further information on the EX-CELL CD Hydrolysate Fusion revolution can be found at (http://www.safcbiosciences.com/ChemicallyDefinedComponents)

About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated services package in mammalian cell culture media development, along with analytical and regulatory support, SAFC Biosciences employs a wealth of industry experience and scientific know-how to deliver reliable, consistent solutions that accelerate customer success - from development through to commercialization. The unit has a 35-year history as a manufacturing partner providing leading biopharmaceutical companies with the broadest range of highly customized products and services possible.

About SAFC: SAFC is the custom manufacturing and services group within Sigma-Aldrich that focuses on high-purity inorganics for high technology applications, cell culture products and services for biopharmaceutical manufacturing, biochemical production and the manufacturing of complex, multi-step organic synthesis of APIs and key intermediates. SAFC has manufacturing facilities around the world dedicated to providing manufacturing services for companies requiring a reliable partner to produce their custom manufactured materials. SAFC has four focus areas - SAFC Pharma(R), SAFC Supply Solutions(R), SAFC Biosciences(R) and SAFC Hitech(R) - and had annual sales of $620 million in 2008. SAFC is one of the world's top 10 fine chemical companies. For more information about SAFC, visit www.safcglobal.com.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its chemical and biochemical products and kits are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development and as key components in pharmaceutical, diagnostic and other high technology manufacturing. The Company has customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has 7,800 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Innovation and Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit its award-winning Web site at http://www.sigma-aldrich.com.

Cautionary Statement: This release contains forward-looking statements relating to future performance, goals, strategic actions and initiatives and similar intentions and beliefs and other statements regarding the Companies' expectations, goals, beliefs, intentions and the like, which involve assumptions regarding the Companies' operations and conditions in the markets the Companies serve. The Companies do not undertake any obligation to update these forward-looking statements.

SAFC(R), SAFC Biosciences(R), SAFC Supply Solutions(R), SAFC Hitech(R), SAFC Pharma(R), and Sigma-Aldrich(R) are registered trademarks of Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.


'/>"/>
SOURCE Sigma-Aldrich
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines
2. Agencourt Genomic Services is Key Collaborator in New Research That Further Defines Landscape of Breast and Colon Cancers
3. Cost-Cutting Plus Value-Add Defines Qualitys Role in a Recession
4. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
5. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
6. InVitria's Cell Culture Media Components Showcased at WilBio's 2008 Cell Engineering Meeting
7. Advanced Bionics Deploys CEVA-TeakLite(TM) DSP Core to Enhance Its Harmony(TM) HiResolution(R) Bionic Ear System
8. ScienceDirect Maximizes Research Capabilities, Enhances the Research Process
9. PharmAthene Enhances Executive Leadership Team and Appoints Joan Fusco, Ph.D. Senior Vice President of Operations
10. Artromick Aligns with McKesson to Enhance Medication Safety at the Patients Bedside
11. Partnership With SearchMedica.com to Enhance Web Searches on ModernMedicine.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
(Date:6/23/2016)... ON (PRWEB) , ... June 23, 2016 , ... STACS ... DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as ... the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... new line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC ... in Chicago. The result of a collaboration among several companies with expertise in ...
Breaking Biology Technology:
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
Breaking Biology News(10 mins):