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S*BIO's Novel JAK2 Inhibitor Pacritinib (SB1518) and Histone Deacetylase Inhibitor Pracinostat (SB939) Demonstrate Promising Activity in Phase 2 Studies for Patients with Myelofibrosis (MF)
Date:11/22/2011

SINGAPORE, Nov. 22, 2011 /PRNewswire/ -- S*BIO Pte Ltd today announced that data from Phase 2 studies for its JAK2 inhibitor pacritinib (SB1518) and histone deacetylase inhibitor pracinostat (SB939) demonstrate promising activity in patients with myelofibrosis (MF). Results will be presented at the 53rd ASH Annual Meeting and Exposition in San Diego, Calif.

"Pacritinib has been well tolerated and has shown activity in alleviating MF-associated splenomegaly and constitutional symptoms with lack of myelosuppression. This is critical to MF patients with impaired hematopoiesis," said Tamar Howson, interim CEO and board member of S*BIO. "Pracinostat showed activity in reducing spleen and/or liver size in MF patients."

Poster: 282, Session:  634. Myeloproliferative Syndromes: Clinical Advances I, Time: 8:15 a.m. PST, Monday, Dec. 12, 2011, Location: Room 6B (San Diego Convention Center)
Results of a Phase 2 Study of Pacritinib (SB1518), a Novel Oral JAK2 Inhibitor, In Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis
Pacritinib showed promising efficacy in alleviating MF-associated splenomegaly and constitutional symptoms at a dose that induces minimal myelosuppression.  Once-daily dosing is well tolerated, with manageable GI toxicity as the main side effect.  Given the lack of myelosuppression with pacritinib, this JAK2 inhibitor is of particular importance for MF patients with impaired hematopoiesis, especially those patients with thrombocytopenia and anemia.

Poster: 3863, Session: 634. Myeloproliferative Syndromes: Clinical Advances I, Time: 6-8 p.m. PST, Monday, Dec. 12, 2011, Location: Hall GH (San Diego Convention Center)
Therapy with the Histone De
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