Navigation Links
S*BIO and Onyx Pharmaceuticals Announce Expanded Development Collaboration for JAK2 Inhibitors
Date:5/4/2010

es, M.D., president and CEO of Onyx. "Expanding our collaboration with S*BIO on these programs fits with Onyx's vision to invest in novel therapies and strengthens our position as an emerging oncology leader."

JAK2 inhibitors are implicated across a broad range of difficult-to-treat illnesses, including cancer and autoimmune diseases, in which patients have mutations and rearrangements of the JAK2 gene. SB1518 (ONX 0803) is a small molecule JAK2-selective kinase inhibitor, which has demonstrated activity against both the wild type JAK2 kinase and the JAK2 kinase with the V617F mutation. The V617F mutation is found in high frequencies in myeloproliferative disorders such as myelofibrosis (MF). It is estimated that approximately 50% of patients with MF possess the JAK2 mutation. SB1518 (ONX 0803) also provides new development pathways for other hematologic malignancies with mutations and rearrangements in the JAK2 gene.  At the recent American Society of Hematology annual meeting, investigators reported encouraging data for SB1518 (ONX 0803) in early stage clinical trials in myeoloproliferative and other hematologic disorders, such as leukemia and lymphoma.

Onyx can elect to exercise its exclusive options for SB1518 (ONX 0803) and SB1578 (ONX 0805) separately and independently at certain predetermined stages of development for each compound in all indications in the United States, Canada and Europe. S*BIO would retain rights to develop and commercialize SB1518 and SB1578 in the rest of the world.

About S*BIO Pte Ltd

S*BIO is a privately-held biotech company focused on the research and clinical development of novel targeted small molecule drugs for the treatment of cancer with leading programs around histone deacetylases (HDAC
'/>"/>

SOURCE S*BIO Pte Ltd; Onyx Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders
2. S*BIO Receives BioSpectrum Editors Choice, Emerging BioScience Company of Singapore Award
3. S*BIO and Tragara Announce an Exclusive Worldwide License Agreement for Novel Multi-kinase Inhibitor SB1317
4. S*BIO Completes US$26 Million Equity Financing
5. S*BIO Receives Orphan Drug Designation for JAK2 Inhibitor SB1518 for the Treatment of Myeloproliferative Disorders
6. Amylin Pharmaceuticals to Present at the Deutsche Bank 35th Annual Healthcare Conference
7. Merrimack Pharmaceuticals Promotes William Sullivan to Vice President of Finance
8. Merrimack Pharmaceuticals Recognized for Innovative Talent Management in HR Executive Magazine's ‘Best HR Ideas for 2010' Issue
9. Shire Receives INTUNIV (TM) Paragraph IV Notice Letter From Teva Pharmaceuticals
10. OncoGenex Pharmaceuticals to Webcast Discussion of Financial Results for Fourth Quarter and Fiscal Year 2009
11. Angiotech Pharmaceuticals, Inc. announces financial results for the fourth quarter ended December 31, 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014  The In Silico Drug Discovery Conference today ... at the conference, which takes place at North Carolina ... 4, 2014. Researchers, students, drug developers, business development professionals, ... KEYNOTE SPEAKERS Ruben ... of Pharmacy Drug Discovery with Three Dimensional ...
(Date:9/17/2014)... JH Technologies announces the grand opening ... JH Technologies, a leader in sales and support of ... partnership with Leica Microsystems into the Southern California market. ... will be featured at the grand opening slated for ... is located within the JH Technologies office’s at 18025 ...
(Date:9/17/2014)... 2014 Hussey Copper , a leader ... antimicrobial copper, announces Gilmour Academy Ice Arena,s conversion of ... antimicrobial solid touch surface to help protect against bacteria.  ... surface that kills greater than 99.9% of MRSA, E-coli ... , Innovative ...
(Date:9/17/2014)... de septiembre de 2014  Cryoport, Inc. ... mundial de soluciones logísticas avanzadas criogénicas para ... vida, anunció hoy la contratación de Broekman ... sede en Rótterdam, Países Bajos, para proporcionar ... en rápido crecimiento. Según los términos del ...
Breaking Biology Technology:In Silico Drug Discovery Conference Announces Speakers and Topics 2In Silico Drug Discovery Conference Announces Speakers and Topics 3In Silico Drug Discovery Conference Announces Speakers and Topics 4In Silico Drug Discovery Conference Announces Speakers and Topics 5In Silico Drug Discovery Conference Announces Speakers and Topics 6In Silico Drug Discovery Conference Announces Speakers and Topics 7JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5
... FRANKLIN LAKES, N.J., May 27 Collagen Matrix, ... States Food and Drug,Administration,s 510(k) clearance of its ... protection of tendon injuries in which,there has been ... Collagen Tendon Wrap is a resorbable type 1 ...
... Planned for September 2008, PLYMOUTH MEETING, Pa., May ... (,BMP Sunstone, or the ,Company,),today announced that it has ... market a new Propess applicator in China., Prior ... dilation to,help induce labor, and is currently distributed via ...
... Judges for Nikon Small World, MELVILLE, N.Y., ... received a record number of entries for the ... by over 300,images. The oldest and most respected ... world,s best photomicrographers who create beautiful,imagery while showing ...
Cached Biology Technology:Collagen Matrix, Inc. Receives FDA 510(k) Clearance for TenoMend(TM) Collagen Tendon Wrap for the Management and Protection of Tendon Injuries 2BMP Sunstone Receives Import Drug License (IDL) from SFDA 2BMP Sunstone Receives Import Drug License (IDL) from SFDA 3Nikon Instruments Receives Record Number of Entries for Nikon Small World 2
(Date:9/17/2014)... USA -- "Nature has developed, very cleverly, some lessons ... in optical design," said Joseph Shaw, director of the ... explore surfaces and structures at the nanoscale, we,ll discover ... San Diego in August during a conference called "The ... and Rongguang Liang of the University of Arizona College ...
(Date:9/17/2014)... Institute of Oncology-Bellvitge Biomedical Research Institute (ICO-IDIBELL), led ... expressed in normal accompanying cells in colorectal tumors. ... classify colorectal tumors, predict the evolution of the ... prevent relapses. , Biomarkers , ... population considering both sexes. About 30,000 new cases ...
(Date:9/17/2014)... faster since the 1960s. The typical development phases of ... accelerated -- by as much as 70 percent. This ... scientists from Technische Universitt Mnchen based on long-term data ... since 1870. Their findings were published recently in ... was a hot topic, with the very survival of ...
Breaking Biology News(10 mins):Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Five genes to predict colorectal cancer relapses 2Global change: Trees continue to grow at a faster rate 2Global change: Trees continue to grow at a faster rate 3
... new study reports for the first time that a less-virulent ... humans. The research appears in the October 1 issue ... Crossing the species barrier is an important step in the ... have focused on the ability of highly pathogenic strains, such ...
... a new study reports for the first time that a ... to humans. The research appears in the October 1 ... , Crossing the species barrier is an important step in ... studies have focused on the ability of highly pathogenic strains, ...
... trials ever, researchers have found that an experimental vaccine ... of shingles--a painful nerve and skin infection--and dramatically reduced ... the disease. The findings appear in the June 2 ... The Shingles Prevention Study, conducted over 5 ½-years, was ...
Cached Biology News:First Whole Genome Map of Genetic Variability in Parkinson’s Disease 2Transplanting Animal Organs Could Soon Be A Reality 2Experimental shingles vaccine proves effective in nationwide study 2Experimental shingles vaccine proves effective in nationwide study 3Experimental shingles vaccine proves effective in nationwide study 4
... This kit is designed for the ... large vector plasmids at any position (for ... included FRT-PGK-gb2-neo-FRT cassette is designed to allow ... eukaryotic cells. It combines a prokaryotic promoter ...
... Agencourt AMPure is a magnetic ... requires no sample transfer, centrifugation ... purifies small and large PCR ... 384-well microplates. Agencourt AMPure can ...
Kit includes your choice of reagents for labeling 3 x 10 9 cells and EasySep magnet....
Plasmid expressing PLAP reporter gene....
Biology Products: