Navigation Links
Rutgers neuroscience may hold key to hearing loss remedy
Date:12/18/2007

he researchers found that two neurotrophin proteins in the cochlea brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) figure prominently in the relay of sound messages to the brain. Research by Davis and her team, begun more than six years ago, is now producing insights into precisely how these multidimensional proteins operate in the cochlea. These most recent findings appear in the Dec. 19 issue of The Journal of Neuroscience.

While neurotrophins have historically been prized for the survival value they impart to nerve cells, the researchers found that in the cochlea they do a great deal more. Their presence in relative proportions transforms the spiral ganglion neurons into either fast-firing transmitters to carry high pitched sound messages to the brain, or slow-firing carriers for the transmission of lower pitched signals. The neurotrophins accomplish this at the molecular level by tightly regulating a newly-defined and complex series of signaling proteins.

Davis explained that one end of the cochlea is home to the slower-firing neurons characterized by a preponderance of NT-3, while the other cochlear end is rich in BDNF, making those neurons faster-firing. Both neurotrophins are present in gradients throughout the range, but at any specific locale their amounts vary relative to each other lots of BDNF and a little NT-3 in the high frequency transmitters, for example, and the reverse as you move toward the other end.

In one possible remedial approach, Davis described how the neurotrophins could potentially be pumped into a newly-designed cochlear implant and released through graduated ports along its length.


'/>"/>

Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Rutgers physicist earns prestigious Packard Foundation Science and Engineering Fellowship
2. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
3. The Debiopharm Life Sciences Award Goes to Dr Nusser for his Outstanding Research in Neuroscience
4. Intellect Neurosciences, Inc. Obtains Validation of European Patent for Alzheimers Vaccine in 19 Countries
5. Dennis L. Smith Appointed Executive Chairman to Board of Directors of Solstice Neurosciences, Inc.
6. Sangamo BioSciences Announces ZFP Therapeutic Data From Nerve Regeneration Program at Society for Neuroscience Meeting
7. Amarin Signs Agreement to Acquire Ester Neurosciences
8. Robert Conley, M.D. to Join Lilly; Will assume a neuroscience leadership role as a Distinguished Lilly Scholar
9. Hearing Scheduled in the Delaware Court of Chancery for August 27, 2007 to Establish the Valid Approval and Consummation of the Merger Between PharmAthene, Inc. and Healthcare Acquisition Corp.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... 14, 2014 As pet owners drew up their lists of ... wrote: "Take better care of my furry companion." Nowadays there are ... top-brand carrying cases to take the little canine or feline darlings ... compelled to buy some pricey toys at the pet store. But ...
(Date:1/14/2014)... Jan. 14, 2014 The largest international professional ... plants and therapeutic derivatives thereof has endorsed an ... researchers about the challenges of adulterated herb and ... The Society for Medicinal Plant ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 iLab Solutions, the ... as the new Director of Product Strategy. In this role, ... as iLab sub-teams to guide in the development of iLab ... provides the maximum possible benefit to the scientific community by ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation ... developing and commercializing innovative therapies addressing major unmet ... it received the Notice of Allowance from the ... unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... call and webcast to begin after markets close at 2:00 p.m. PT ... ... Masimo Corporation,(Nasdaq: MASI ), the inventor of Pulse CO-Oximetry and,Measure-Through-Motion- ... the period ended,September 27, 2008 after the market closes on Monday, October ...
... Oct. 15 PURE Bioscience (Nasdaq:,PURE), creators of ... revenues for the fiscal year ended July 31, ... with $336,400 in the,prior fiscal year. The Company ... or $(0.24) per share, compared with a loss ...
... Agency Expanding Industry Connections, MOUNTAINSIDE, N.J., Oct. ... medical education company,today announced the hiring of Todd ... leverage his experience in medical education and,publishing as ... L&M, he,served as Manager of Publication Sales at ...
Cached Biology Technology:Masimo to Report Third Quarter 2008 Financial Results on October 27, 2008 2PURE Bioscience Reports Fourth Quarter and Year End Results 2PURE Bioscience Reports Fourth Quarter and Year End Results 3PURE Bioscience Reports Fourth Quarter and Year End Results 4PURE Bioscience Reports Fourth Quarter and Year End Results 5PURE Bioscience Reports Fourth Quarter and Year End Results 6PURE Bioscience Reports Fourth Quarter and Year End Results 7L&M Healthcare Communications LLC Expands Client Services With Executive Team Expansion 2
(Date:7/9/2014)... Bacterial infections usually announce themselves with pain and fever but ... are those that are sneaky and hard to beat. Now, ... the form of tiny DNA pyramids. Published in the journal ... the nanopyramids can flag bacteria and kill more of them ... note that some infectious pathogens can lie in wait, undetectable ...
(Date:7/9/2014)... by researchers at the NIH,s National Center ... collaborators to treat sickle cell disease has ... The drug candidate, Aes-103, is the first ... mechanism of sickle cell disease. Baxter now ... for regulatory approval and commercialization. , Sickle ...
(Date:7/9/2014)... vitamin D in their blood are more likely to survive ... highest levels of vitamin D have half the risk of ... reveal. , The study is the first to correlate total ... their diagnosis which includes that produced after exposure to ... long term survival prospects. , The University of Edinburgh ...
Breaking Biology News(10 mins):First drug candidate from NIH program acquired by biopharmaceutical company 2First drug candidate from NIH program acquired by biopharmaceutical company 3First drug candidate from NIH program acquired by biopharmaceutical company 4
... Foundation announced that five scientists with novel approaches to ... Damon Runyon-Rachleff Innovation Award. The grant of $450,000 ... career scientists whose projects have the potential to significantly ... The 2011 Damon Runyon-Rachleff Innovators are: ...
... Frontotemporal dementia is caused by a breakdown of nerve ... brain (fronto-temporal lobe), which leads to, among other symptoms, ... some forms of frontotemporal dementia is a genetically determined ... Dr. Anja Capell and Prof. Christian Haass have now ...
... Invasive plant species are a serious environmental, economic and ... native biodiversity and ecosystem functions, such as nutrient cycling. ... why some species dominate new habitats over native plants ... but rarely tested assumption, say biologists, is that these ...
Cached Biology News:Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research 2Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research 3Malaria medication may help against 1 type of frontotemporal dementia 2Home and away: Are invasive plant species really that special? 2
Rabbit polyclonal to Staphylococcus Enterotoxin E (Biotin) ( Abpromise for all tested applications)....
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
... siSolutions siRNA Custom Synthesis ... effective duplex RNA to knockdown ... 21-mers (19 RNA base pairs ... recently-published 27-mers, or other lengths ...
... first fully genetically encoded fluorescent sensor capable ... peroxide (H2O2), one of the main ROS ... of yellow fluorescent protein inserted into the ... (OxyR-RD), HyPer demonstrates submicromolar affinity to H2O2 ...
Biology Products: