Rosetta Genomics to Present Multiple Posters at the Annual American Association of Cancer Research (AACR) ... (hich assigns aprimary site to a cancer s...)

Rosetta Genomics to Present Multiple Posters at the Annual American Association of Cancer Research (AACR) Conference

Date:4/11/2008

hich assigns a primary site to a cancer sample based on the microRNA expression in the sample. The overall sensitivity of this classifier is approximately 85%, with two-thirds of the samples being classified with high-confidence, reaching accuracy exceeding 90% and specificity of 99%.

3. "Antisense oligonucleotides against microRNA as a novel therapy for hepatocellular carcinoma"; Sunday April 13, exhibit hall B-F, poster section 32, poster board 12, abstract # 1505.

MicroRNAs' regulatory role makes them attractive potential targets for therapeutics, through either their activation or suppression. Rosetta Genomics Scientists, in collaboration with scientists from Isis Pharmaceuticals, Inc., aim to identify microRNAs that are deregulated in hepatocellular carcinoma (HCC) and inhibit their activity through the use of antisense oligos (ASO). ASOs that target microRNAs which prove to be involved in the carcinogenic process can be used as potential novel therapeutic agents for the treatment of HCC.

4. "MicroRNA profiles in body fluids as a novel class of biomarkers", Wednesday April 16, exhibit hall B-F, poster section 3, poster board 22, abstract #5167.

Rosetta Genomics has developed an integrative robust platform for extracting and profiling of microRNAs from body fluids including from the cell-free fraction of these fluids. The protocol was successfully applied to all body fluids and cell-free fluids examined, including serum, urine, saliva, amniotic fluid and pleural fluid.

About MicroRNA

MicroRNAs (miRNAs) are recently discovered, naturally occurring, small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by the abnormal activity of proteins, the ability to selectively regulate protein activity through microRNAs could provide the means to treat a wide range of human diseases. In addition, microRNAs have been shown to ha
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Rosetta Genomics to Present Multiple Posters at the Annual American Association of Cancer Research (AACR) ...(hich assigns aprimary site to a cancer s...)