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Rosetta Genomics and Columbia University Medical Center to Develop MicroRNA-based Diagnostics for Leukemia and Non Hodgkin Lymphoma
Date:12/13/2007

hese NHL indications.

Diffuse Large Cell Lymphoma (DLCL) and Transformed Follicular Lymphoma are the two most common types of NHL, accounting for approximately 45 percent of all new non NHL cases. Chronic Lymphocytic Leukemia (CLL) is a type of cancer that starts in blood-forming cells of the bone marrow. It then invades the blood and can spread to other parts of the body, including the spleen. According to the American Cancer Society, in the US alone approximately 43,000 people will be diagnosed with these types of cancers in 2007.

"40 percent of DLCL patients respond well to current therapies and have prolonged survival, whereas the remainder succumb to the disease, and we do not know why," said Dalia Cohen, Global Head of R&D at Rosetta Genomics. "We believe our technology will help answer this question, as well as speed up and simplify the diagnostic process."

"MicroRNAs perform their regulatory function on key cellular processes further up-stream than other currently used biomarkers," explained Dr. Riccardo Dalla-Favera, professor of Pathology, director of the Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center. "This is most likely the reason why they are proving to be such good biomarkers. The technologies developed through our collaboration with Rosetta Genomics are very sensitive. Our hope is that by working together, we can continue to take important steps toward better diagnostic tests for cancer patients."

About microRNAs

MicroRNAs (miRNAs) are recently discovered, naturally occurring small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by the abnormal activity of proteins, the ability to selectively regulate protein activity through microRNAs could provide the means to treat a wide range of human diseases. In addition, microRNAs have been shown t
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