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Romark Announces Final Data From Clinical Trial of Nitazoxanide in Treatment-Naive Patients With Genotype 1 Chronic Hepatitis C
Date:5/4/2010

eplicon studies, (4) and laboratory studies indicate that it does not induce viral mutations that confer drug resistance. (5)  Nitazoxanide is synergistic with interferon and direct acting antivirals in replicon studies. (4,6)  In patients with chronic hepatitis C, the addition of nitazoxanide has not resulted in an increase in the toxicity associated with peginterferon and ribavirin.  Studies in patients with genotype 4 chronic hepatitis C suggest that nitazoxanide may be used to replace ribavirin. (1,2)  The AIDS Clinical Trials Group (ACTG) in the United States is studying nitazoxanide plus peginterferon and ribavirin for treating chronic hepatitis C in patients coinfected with HIV.

"Patients with chronic hepatitis C are diverse in many respects with patient and virus characteristics that affect treatment outcomes (HCV genotype, viral load, stage of liver disease, IL28B genotype, race, body weight, coinfection with HIV or hepatitis B virus, and ability to tolerate treatment)," said Emmet B. Keeffe, Chief Medical Officer of Romark Laboratories.  "The trend in therapy of chronic hepatitis C has been toward individualized therapy with combinations of antiviral drugs.  There is a need for a new class of safe drugs with novel mechanism that can be used in combination with current standard therapy or with other new classes of drugs to improve treatment outcomes.  We believe nitazoxanide can play an important role in these combinations."

About Hepatitis C

Hepatitis C is a blood-borne infectious disease that is caused by the hepatitis C virus (HCV). It is the most common cause of chronic hepatitis in the U.S. and may eventually lead to cirrhosis, liver cancer and liver failure. The disease is transmitted by contact with HCV-infected blood.  A large majority of those i
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SOURCE Romark Laboratories, L.C.
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1. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
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4. Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at AASLD 2008
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