Navigation Links
Roche Researchers Sequence Complete Genome of Cynomolgus Monkey and Develop Novel Gene Expression Microarray for Drug Safety Assessment
Date:9/22/2011

BASEL, Switzerland, September 22, 2011 /PRNewswire/ --

A team of researchers from Roche (SIX: RO, ROG; OTCQX: RHHBY), including scientists from Roche Pharma Research and Early Development and Roche NimbleGen, reported inGenome Research (1) that they have generated the first draft genome sequence of the cynomolgus monkey (Macaca fascicularis) and developed a novel microarray design for in depth expression profiling for use in preclinical drug safety research.

The cynomolgus macaque is one of the most important and widely used non-human primate animal models in basic and applied biomedical research. Compared to other species, non-human primates have a closer evolutionary relationship to humans and exhibit high physiological similarity well suited to serve as translational models for preclinical drug safety assessment.

To improve the predictive power of primate experiments for humans, Prof. Ulrich Certa, Global Head Molecular Toxicology, and his team first applied a shotgun sequencing strategy using the Genome Sequencer FLX System from Roche's 454 Life Sciences division in combination with other next generation sequencing technologies to decode the entire genome of a Macaca fascicularis female of Mauritian origin with 6-fold coverage. In addition, roughly two million potential single-nucleotide polymorphisms (SNPs) were discovered which, for the first time, will allow high-resolution genotyping of individuals in this species.

Using a combination of sequence alignment and exon size conservation, more than 20,000 transcripts in the cynomolgus monkey genome were predicted and used to build a M. fascicularis-specific gene expression microarray on the Roche NimbleGen 12x135K platform, in less than two months enabling comprehensive yet economical transcriptome analysis. The 12-plex expression array format contains 135,000 oligonucleotide features per array with six 60-mer pro
'/>"/>

SOURCE Roche Diagnostics GmbH
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. Roche Submits Acute Hepatitis B Test to FDA for Premarket Approval
2. China Agri-Business Acquired Management and Operation Rights of Shaanxi Qinfeng Agrochemical Inc. in Xian, China
3. Proceedings of the National Academy of Sciences (PNAS) Publishes Roche Manuscript on Production of Bispecific IgG Antibodies
4. Roche Building Awarded LEED® Gold Certification
5. Rules-Based Medicine Reaches a Significant Milestone in Companion Diagnostic Program With Roche
6. Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children
7. Roche Diabetes Care in the U.S. Turns to Social Media to Promote Diabetes Education, Awareness and Advocacy
8. Pivotal Study Validates Roches cobas® HPV Test with HPV-16 and 18 Genotyping for Identifying Women at Highest Risk for Cervical Cancer
9. Halozyme Announces Roche Doses First Patient in Phase 3 Clinical Trial With Subcutaneous MabThera® (rituximab)
10. Roche, Baylor Research Institute Partner in Human Immunology Research
11. Roche Diabetes Care Forms Human Blue Circle, Supports Viral Video for World Diabetes Day
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... Lake, MN (PRWEB) May 21, 2013 The ... trade show display solution for sales and marketing teams looking ... Displays describes the kit as “everything you’ll need to ... Fusion Fabric Display Kit comes with a number of displays ... all-around trade booth 20 feet by 20 feet in size. ...
(Date:5/20/2013)... (PRWEB) May 20, 2013 Oven Industries ... with ramp/soak capabilities. The 5R6-900 benchtop controller has many ... device can be plugged into the wall as a ... supply. This distinctive detail makes the device unique, as ... The laboratory temperature controller can also be used universally, ...
(Date:5/20/2013)... 20, 2013  Dr. Gerald Zon ... research, recently launched a new blog in conjunction with ... zon.trilinkbiotech.com ), focuses on what,s trending in the field ... thought leaders, discussions of research presented at conferences and ... Dr. Zon (PhD Princeton University 1971) developed automated ...
(Date:5/20/2013)... CHAPEL HILL, N.C. , May 20, 2013 ... pharmaceutical company focused on developing differentiated antibiotics to ... bacterial infections, today announced that it presented data ... 2013) in Philadelphia demonstrating ... versus levofloxacin in Cempra,s prior Phase 2 clinical ...
Breaking Biology Technology:GLM Displays Announces All-in-One Formulate Fusion Fabric Display Kit 2New Laboratory Temperature Controller by Oven Industries 2Dr. Gerald 'Jerry' Zon Launches New Blog for TriLink BioTechnologies 2Cempra Presents Post-Phase 2 Analysis of Solithromycin's Efficacy and Safety Results from Patients with Community Acquired Bacterial Pneumonia (CABP) 2
... July 5, 2011 Cellectis bioresearch, a subsidiary ... customization, has received the "Most Innovative New Service ... Access service offering. TALENs(1) allow for customized gene ... powerful and now affordable new tool. This prize ...
... 2011 Genesis Biopharma, Inc. (OTC/BB: GNBP), a ... Laszlo Radvanyi, Ph.D., an Associate Professor in the ... University of Texas MD Anderson Cancer Center in ... Board.  MD Anderson is one of the world,s ...
... 5, 2011 Cord Blood America, Inc . (OTC ... entered into an agreement with Regence ( www.regence.com/index.jsp ) to ... its BlueCross and BlueShield plans in Idaho, Oregon, Utah and ... BlueShield (BCBS) licensee contracts. The partnership gives Regence ...
Cached Biology Technology:TALEN® Access by Cellectis Bioresearch Receives "Most Innovative New Service 2011" Award at Life Science Awards 2Laszlo Radvanyi, Ph.D. Joins Genesis Biopharma Scientific and Medical Advisory Board 2Laszlo Radvanyi, Ph.D. Joins Genesis Biopharma Scientific and Medical Advisory Board 3Cord Blood America Enters Agreement With Regence, Serving BlueCross and BlueShield Programs in the Northwest U.S. and Mountain Regions 2
(Date:5/20/2013)... MINNEAPOLIS/ST. PAUL (MAY 20, 2013) University of Minnesota ... of Minnesota, in partnership with the University,s Brain Tumor ... peripheral nerve sheath tumors (MPNST) that allow them to ... of cancer. , The research was published this week ... the Sleeping Beauty transposon method, researchers in the lab ...
(Date:5/20/2013)... The Amazon rain forest, popularly known as the lungs of ... use carbon dioxide from the air to grow parts that ... away by the region,s plentiful rainfall. , Until recently ... the Amazon River and ended up deep in the ocean. ... exhale huge amounts of carbon dioxide though left open ...
(Date:5/20/2013)... - A National Science Foundation (NSF) planning grant will ... (CARD), a joint program of the University of Illinois ... Mass. , "CARD will be devoted to research in ... agricultural products; forestry and paper products; chemical products; textiles; ... professor of food science and human nutrition and the ...
Breaking Biology News(10 mins):U of M researchers develop model for better testing, targeting of MPNST 2Amazon River exhales virtually all carbon taken up by rain forest 2Amazon River exhales virtually all carbon taken up by rain forest 3NSF approves planning grant for Center for Advanced Research in Drying 2
... , A series of papers published this month on ecological ... by the University of Colorado Boulder in the high mountains ... seasonal snow and ice are the most sensitive to changes ... April issue of the journal BioScience. The papers were ...
... Ga. Soldiers in war zones and farmers tending their ... impact their nerves. In large doses these agents, called ... can also produce chronic disabilities such as problems with learning ... Terry Jr., pharmacologist at the Medical College of Georgia at ...
... Clean drinking water and basic sanitation are human rights. ... have no access to drinking water and some 2.6 ... also an important economic factor: Today, agricultural and manufacturing ... this precious commodity. And the demand for water continues ...
Cached Biology News:CU research shows warming climate threatens ecology at mountain research site west of Boulder 2CU research shows warming climate threatens ecology at mountain research site west of Boulder 3Effect of chronic exposure to chemicals used as weapons, pesticides under study 2Effect of chronic exposure to chemicals used as weapons, pesticides under study 3Use less water, producing energy and fertilizer at the same time 2Use less water, producing energy and fertilizer at the same time 3
RABBIT ANTI HUMAN ALPHA-2-ANTIPLASMIN...
... DNA Polymerase with a proprietary thermostable proofreading ... than standard Taq DNA polymerase, Double the ... DNA templates >20kb, Concentration: 5U/ul, Applications: high ... and mutagenesis We are part of Thermo ...
... EnzChek Lysozyme Assay Kit (E-22013) provides,researchers ... levels of lysozyme,activity in solution. This ... to 20 U/mL (Figure 1). The ... cell,walls, which are labeled to such ...
... based on measurenment of enzyme activity of ... microtiter plate. The procedure includes two incubation ... 2nd enzyme reaction) separated by a ... the determination of human enzymaticaly active TRAP ...
Biology Products: