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Robert Kirsner, MD, PhD, To Present Results For Phase 2b 6-Month Follow-Up Trial Of Unique Investigational Cell-Based Therapy For Venous Leg Ulcers
Date:7/25/2012

g this 6-month follow-up period, though subjects in the vehicle group crossing over to the open-label extension were allowed to receive other active interventions. Consistent with the results observed during the 12-week double-blind treatment period, the best dose group continued to perform best throughout the open-label follow-up study. At the end of the open-label follow-up study, 83% of wounds were healed in this cell-treated group vs. 58% in the vehicle group. Overall, most of the wounds healed at the end of the double-blind study remained healed at the end of the follow-up study, regardless of treatment group.

"Benefits in the active treatment groups were found to persist through six months of follow-up after dosing had stopped," noted Bert Slade, MD, FAAAAI, Chief Medical Officer at Healthpoint Biotherapeutics. "The durability of healing is just as important as getting the wound healed in the first place."

"The benefit of cell therapy persisted, both in terms of healed wounds remaining closed and the proportion of healed wounds exceeding what was seen in the control group," added Dr. Kirsner, who served as one of the lead investigators for the trial and is a tenured Professor and Vice Chairman in the Department of Dermatology and Cutaneous Surgery at the University of Miami Miller School of Medicine. "Despite receiving a variety of available treatments during this six month follow-up, the vehicle group never achieved a comparable proportion of wounds closed."

About HP802-247
HP802-247 is an investigational allogeneic living human cell bioformulation that consists of two components that are sprayed sequentially on the wound bed at the time of treatment: a fibrinogen solution and a cell preparation containing a mixture of growth arrested, living, allogeneic epidermal keratinocytes and dermal fibroblasts.

Based on in vitro studies, HP802-247 is believed to release various growth factors and cytokines into the micro-environ
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SOURCE Healthpoint Biotherapeutics
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