Navigation Links
Road block as a new strategy for the treatment of Alzheimer's
Date:8/22/2011

Blocking a transport pathway through the brain cells offers new prospects to prevent the development of Alzheimer's. Wim Annaert and colleagues of VIB and K.U. Leuven discovered that two main agents involved in the inception of Alzheimer's disease, the amyloid beta precursor protein (APP) and the beta secretase enzyme (BACE1), follow a different path through the brain cells to meet up. It is during the eventual meeting between protein and enzyme that the basis is laid for the development of the disease. The results of the study were published in the Proceedings of the National Academy of Sciences.

Wim Annaert suggests that "closing off or rerouting the path which beta secretase follows to get to APP may perhaps be used to inhibit the rise of the disease. However, a great deal of additional research will be necessary to confirm whether this discovery can effectively lead to a drug."

Inhibiting the formation of amyloid plaques

The presence of amyloid plaques is typical of the brains of Alzheimer patients. These plaques are abnormal accumulations of a sticky short protein (beta amyloid) between the nerve cells. The beta amyloid peptide develops when the APP precursor protein is cut into pieces the wrong way, in a reaction which also involves the beta secretase enzyme. Overproduction of these peptides may give rise to the formation of plaques. The plaques disrupt the normal functioning of the brain. Preventing the formation of these plaques is a possible strategy for inhibiting the disease.


'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1

Related biology technology :

1. Newly designed molecule blocks chlamydia bacteria
2. Convergence Pharmaceuticals Announces Start of Phase II Study for its Selective Nav 1.7 blocker CNV1014802
3. Jeff Sherman Joins Block Engineering as Vice President of Worldwide Sales
4. New kid on the plasmonic block
5. Cord Blood America: Court Grants Motion to Dismiss at Lawsuit Aimed at Blocking Acquisition
6. Blocking carbon dioxide fixation in bacteria increases biofuel production
7. TU scientists in Nature: Better control of building blocks for quantum computer
8. World-first to provide building blocks for new nano devices
9. Magnetic fields drive drug-loaded nanoparticles to reduce blood vessel blockages in an animal study
10. Viroblock SA Hires Dr. Jamie Paterson as CEO and Closes Financing Round
11. Women More Likely Than Men to Avoid Amputation After Minimally Invasive Therapy for Blocked Leg Arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... (PRWEB) , ... January 23, 2017 , ... Oklahoma City ... the newest client for the firm’s PERFEQTA software and legacy product QC Manager 2.0. ... with the dynamic team at CJBC and thrilled that they have decided to implement ...
(Date:1/24/2017)...   Instrument Business Outlook ( IBO ... ) the 2016 Company of the Year. ... tracking developments in the analytical and life science ... achieved outstanding technical, operational and financial results throughout ... IBO. "In 2016, Bio-Techne capitalized on opportunities in ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... telemedicine company announces significant growth last year adding 65 new US and international ... US Army medical centers as well as one of US largest imaging center ...
(Date:1/23/2017)... , Jan. 23, 2017 /PRNewswire/ - Resverlogix Corp. ("Resverlogix" ... from the New Zealand based ... The data showed remarkable results in reducing inflamed protein ... control patients. It is believed that this is the ... of this type can be made between epigenetic regulation ...
Breaking Biology Technology:
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  For the thousands of attendees ... a global leader in connected health and biometric measurement devices and services, ... monitors. On display in A&D Medical,s special CES Exhibit ... represent the ongoing expansion of the company,s WellnessConnected product platform.  ... ...
(Date:1/3/2017)... -- Onitor, provider of digital health technology for consumers, ... biometric data-driven program designed to aid weight loss for ... Consumer Electronics Show (CES) in Las Vegas ... World Health Organization (WHO), have identified lifestyle risks that ... overweight or obese. WHO also states that more people ...
(Date:12/22/2016)... 2016 SuperCom (NASDAQ:   ... the e-Government, Public Safety, HealthCare, and Finance sectors announced today that ... selected to implement and deploy a community-based supportive services program to ... , further expanding its presence in the state. ... This new program, which is ...
Breaking Biology News(10 mins):