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RiskMetrics (ISS), An Independent Proxy Advisory Firm, Recommends Voting the GOLD Card for Four of PTV's Nominees: Anderson, McInerney, Melrose, and O'Holla
Date:9/11/2008

in the areas of marketing and developing partnerships between small and large biopharma companies, obtaining external market exposure and managing investor expectations, and providing medical, regulatory and financial expertise to the board."

The RiskMetrics report concludes with a powerful recommendation that InSite Vision stockholders for vote the GOLD card, stating that "We believe that change in this case is preferable to the status quo and believe that some of the dissident [PTV] nominees will add value to board deliberations and enhance management oversight that is more likely to create long term shareholder value. We believe Mr. Anderson's big pharma marketing experience, Mr. McInerney's finance experience, Mr. Melrose's medical and healthcare experience and Mr. O'Holla's big pharma regulatory affairs experience will be beneficial to the board in this respect." The report concludes that "we note that the dissidents have met the burden of proof that change is warranted and have provided a detailed plan."

All stockholders are encouraged to sign, date and return the GOLD proxy card. You may also vote by phone or on the Internet by following the instructions on the GOLD proxy card. Do not return any WHITE proxy card that you receive from management. If you have any questions or need assistance voting your shares, please contact MacKenzie Partners, Inc., which is assisting us in this matter, toll-free at (800) 322-2885 or insiteproxy@mackenziepartners.com.

About PTV Sciences

PTV Sciences ("PTV") is a healthcare venture capital and growth equity firm focused on enabling healthcare entrepreneurs and global innovation. We are a highly collaborative investment team of 22 professionals, deeply experienced as investors and operators of life science companies. PTV Sciences focuses on enabling industry leading companies and investing in extraordinary people in the healthcare and life sciences sector, including ophthalmology, medical devices, bi
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