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Rising Replikin Counts in E. Coli in Germany Since 2005 Preceded Current E. Coli Outbreak
Date:6/20/2011

LONDON, June 20, 2011 /PRNewswire/ -- Scientists Drs. Samuel and Elenore Bogoch of BioRadar UK Ltd. announced that retrospective studies indicate that an increase in Replikin Counts of the EHEC lethal strains of E. Coli preceded the current E. Coli outbreak. These EHEC strains of E. Coli have been studied in laboratories in Germany and elsewhere since 1995, and genome sequences are consequently available in the public databases. Replikins are subsequences of the genome of an infectious agent that have been correlated with virulence across a range of diseases. Just as the H1N1 pandemic of 2009 was predicted in 2008 because of Replikin Count increases, E. Coli Replikin Counts (number of replikins per 100 amino acids) increased from 1.9 (+/- 1.2) in 2005, to 3.7 (+/- 2.9) in 2009 and to 14.2 in 2011. Twenty-nine individual Replikin sequences identified so far, conserved in the genomes of these hemorrhagic E. Coli strains, have been traced back from 2011: twenty-five of them to 1999, and four to 1995. To date, no other structures of infectious organisms have been described that correlate quantitatively and temporally with epidemic outbreaks, course, and lethality, and permit early or advance strain-specific warning of such outbreaks.

Replikins are genomic structures related to rapid replication, defined by Replikins Ltd. and BioRadar's proprietary and patented algorithm as peptides 7 to 50 amino acids long, containing two or more lysines, six to ten amino acids apart, at least one histidine, and a lysine concentration of 6% or more. As Replikins increase in number, they have been observed by linear and three-dimensional x-ray diffraction studies to expand and spread on the surface of the hemagglutinin gene of the influenza virus.

How reliable a signal is an increase in Replikin Count? To date, the Replikins science team has studied over 30,000 genomic sequences from a period of 94 years as published in PubMed. Statistically significant increases in Rep
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SOURCE BioRadar UK Ltd.
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