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Rising H9N2 Influenza Replikin Count Has Doubled That of H5N1
Date:1/16/2009

than those in its first cycle, and double those seen to date in all H5N1 and other influenza strains (see refs.). This phenomenon of upregulation of the Replikin Peak Gene in successive replikin cycles in advance of increasing annual human morbidity has also been found by the Drs. Bogoch in West Nile Virus as it entered and expanded into the United States (see refs).

Virus replikins thus provide, to our knowledge, the first quantitative measures of virus structural change ever shown to correlate with and to precede virus outbreaks. Cycles of rapid replication of the virus with increasing replikin counts appear to be a means of virus expansion into new host populations and geographic areas, and of increasing infectivity and lethality.

The data suggests that additional increases in both Replikin Counts and consequent H9N2-H5N1 infections are anticipated in a coming third cycle. Suggesting that a third cycle has begun, after a 5 year absence, H5N1 reappeared in Hong Kong chickens in early December 2008. and an H9N2 infection in a child in Hong Kong was reported on 12/30/2008.

With this new ability to obtain advance virus structural information on coming outbreaks, the rapid (7 day) production of specific effective synthetic replikin vaccines is now possible, as Replikins, Ltd. has reported for a synthetic Taura Syndrome virus oral vaccine 91% protective in shrimp (see refs.).

References and Notes:
Detailed replikins data are published at the uspto website.
Replikins, Ltd. now is publishing two monthly e-mail reports by subscription:
1)   "FluForecast®" - monthly replikins reports on influenza strains ($1,200. per year); and
2)   "ReplikinsForecast®"- monthly replikins reports on non-influenza viral, bacterial, trypanosomal, and other emerging infectious diseases ($1,200. per year).

To order, e-mail jmckenney at replikins dot com.

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