Navigation Links
Rising H9N2 Influenza Replikin Count Has Doubled That of H5N1
Date:1/16/2009

The H9N2 strain of influenza commonly infects poultry and occasionally humans. Replikins, Ltd., using its FluForecast® software, has studied the Replikin Count® annually in each of H9N2 and its sister strain H5N1. Cyclic increases and decreases appear to be synchronous for H9N2 and H5N1, with H9N2 increases occurring in advance of, and being greater than those for H5N1. These two strains appear to have a precursor and/or competitor, evolutionary biochemical relationship. H9N2 may be an alternate candidate to H5N1 for the next influenza pandemic.

Boston, MA (PRWEB) January 16, 2009 -- The H9N2 strain of influenza commonly infects poultry and occasionally humans. Replikins, Ltd., using its FluForecast® software, has studied the Replikin Count® annually in each of H9N2 and its sister strain H5N1. H9N2 Count increases occurred in 1996, one year in advance of the 1997 H5N1 Hong Kong outbreak, and again in 1999-2000 and 2004-05, 2 years before the subsequent H5N1 Replikin Count increases and outbreaks (see Figure). Cyclic increases and decreases appear to be synchronous for H9N2 and H5N1, with H9N2 increases occurring in advance of, and being greater than those for H5N1. These two strains appear to have a precursor and/or competitor, evolutionary biochemical relationship. H9N2 may be an alternate candidate to H5N1 for the next influenza pandemic.



The Replikin Count® is the number of specific replikin peptides per 100 amino acids in the peak gene of each strain. All sequences published on PubMed worldwide. each year from 1992 to 2008 were studied. Increases in the Replikin Count represent rapid virus replication, and occur in advance of outbreaks (see refs).

The first cycle which has been detected in each virus genome is from 1999 to 2003, and the second from 2004 to 2008. In the second cycle, the maximal Replikin Counts (mean +/-SD) for H9N2 were greater than those in its first cycle, and double those seen to date in all H5N1 and other influenza strains (see refs.). This phenomenon of upregulation of the Replikin Peak Gene in successive replikin cycles in advance of increasing annual human morbidity has also been found by the Drs. Bogoch in West Nile Virus as it entered and expanded into the United States (see refs).

Virus replikins thus provide, to our knowledge, the first quantitative measures of virus structural change ever shown to correlate with and to precede virus outbreaks. Cycles of rapid replication of the virus with increasing replikin counts appear to be a means of virus expansion into new host populations and geographic areas, and of increasing infectivity and lethality.

The data suggests that additional increases in both Replikin Counts and consequent H9N2-H5N1 infections are anticipated in a coming third cycle. Suggesting that a third cycle has begun, after a 5 year absence, H5N1 reappeared in Hong Kong chickens in early December 2008. and an H9N2 infection in a child in Hong Kong was reported on 12/30/2008.

With this new ability to obtain advance virus structural information on coming outbreaks, the rapid (7 day) production of specific effective synthetic replikin vaccines is now possible, as Replikins, Ltd. has reported for a synthetic Taura Syndrome virus oral vaccine 91% protective in shrimp (see refs.).

References and Notes:
Detailed replikins data are published at the uspto website.
Replikins, Ltd. now is publishing two monthly e-mail reports by subscription:
1)   "FluForecast®" - monthly replikins reports on influenza strains ($1,200. per year); and
2)   "ReplikinsForecast®"- monthly replikins reports on non-influenza viral, bacterial, trypanosomal, and other emerging infectious diseases ($1,200. per year).

To order, e-mail jmckenney at replikins dot com.

###

Read the full story at http://www.prweb.com/releases/Replikins/H9N2/prweb1874064.htm


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Related biology technology :

1. International Diabetes Experts Call for Stepped-Up Action and Shared Responsibility to Curb Rising Global Diabetes Epidemic and Impact
2. Jatropha World 2009 Advance Access: Surprisingly Candid Interview Series Examines Biofuel Predictions Compared to Fossil Fuels
3. Jatropha World 2009 Advance Access: Surprisingly Candid Interview Series Examines Biofuel Predictions Compared to Fossil Fuels
4. MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production
5. Sanofi Pasteurs Investigational H5N1 Influenza Vaccine Achieves High Immune Response at low Dosage
6. BioCryst Reports Preliminary Results From a Phase II Clinical Trial of Peramivir in Subjects With Acute Influenza
7. European Expert Consortium Combines Forces to Develop a Novel Pandemic Influenza Vaccine
8. Protherics Licenses its CoVaccine HT Adjuvant to Nobilon for Influenza Vaccine Indications
9. Enigma Diagnostics Announces a European Commission Award of EUR3 Million to Fund the Development of a Point of Care Platform for the Rapid Diagnosis of Influenza Infections
10. Vical Presentation at Military Pandemic Influenza Workshop
11. Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rising H9N2 Influenza Replikin Count Has Doubled That of H5N1
(Date:10/9/2017)... Phoenix, Arizona (PRWEB) , ... October 09, 2017 ... ... of Kindred, a four-tiered line of medical marijuana products targeting the needs of ... production and packaging of Kindred takes place in Phoenix, Arizona. , As operators ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... for microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical ... broad range of contract analysis services for advanced applications. Services will leverage ...
(Date:10/7/2017)... Mass. , Oct. 6, 2017  The ... work of three scientists, Jacques Dubochet, Joachim ... breakthrough developments in cryo-electron microscopy (cryo-EM) ... technology within the structural biology community. The winners ... Scientists can now routinely produce highly resolved, three-dimensional ...
(Date:10/6/2017)... , ... October 06, 2017 , ... ... a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial for ... Dana-Farber Cancer Institute. The event is free and open to the public, but ...
Breaking Biology Technology:
(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) is ... tech event dedicated to developing collaboration between startups and global ... June 15-17. During the event, nine startups will showcase the ... in various industries. France ... international market, with a 30 percent increase in the number ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
Breaking Biology News(10 mins):