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Riordan Clinic Research Institute Has Developed and Patented a Process for the Assessment of the Energy Metabolism in Patients with Chronic Fatigue Syndrome
Date:4/11/2012

analysis, based on the correlation matrix between all variables, demonstrated that the best correlations were between the NAD(P)H, serum coenzyme Q10 and urine pyrroles.

As coenzyme Q10 is the component of a complex series of reactions that occur within mitochondria, the function of Q10 ultimately is linked to the generation of energy within the cells.  The correlation between the lower level of coenzyme Q10 and lower NAD(P)H signals for patients with CFS suggests lower bioenergetics for these subjects.

An inverse correlation was found between the level of serum emission and the level of pyrroles in urine. The pyrroles are often elevated in patients with mental illness. This molecule is well known for bio-toxicity and is associated with emotional stress.

As a result of the study, researchers proposed that fatigue level and metabolic slowdown in CFS patients can be evaluated and monitored by serum NAD(P)H concentration measurements.

The measurement of the fluorescence of reduced nicotinamide adenine dinucleotide in serum provides a non-invasive assay to estimate metabolism and fatigue levels in CFS patients.  Following patient NAD(P)H levels over time may aid in selecting therapeutic strategies and monitoring treatment outcome.

To read this and other articles written by Riordan Clinic researchers, go to http://www.riordanclinic.org/research/journal-articles.shtml.

The Riordan Clinic is a progressive nutrition-based medical clinic located in Wichita, Kansas. For 36 years, the Riordan Clinic has integrated lifestyle and nutrition to help patients find the underlying causes of their illness. Since the inception in 1975, the mission has been clear and unwavering to "…stimulate an epidemic of health."

If you would like more information about this topic, please call Tiffany Hurley at (316) 682-3100 or email at

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