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Riordan Clinic Research Institute Has Developed and Patented a Process for the Assessment of the Energy Metabolism in Patients with Chronic Fatigue Syndrome
Date:4/11/2012

WICHITA, Kan., April 11, 2012 /PRNewswire-USNewswire/ -- Riordan Clinic scientists Dr. Nina Mikirova, Dr. Joseph Casciari, and Dr. Ronald Hunninghake have patented a new technology that may help doctors determine the severity of fatigue in their patients.  The research, recently published in the January/February issue of the journal, Alternative Therapies, is entitled "The Assessment of the Energy Metabolism in Patients with Chronic Fatigue Syndrome by Serum Fluorescence Emission." 

Chronic fatigue syndrome (CFS) is characterized by long-lasting disabling fatigue. It includes non-specific symptoms such as weakness, malaise, subjective fever, sore throat, lymph node pain, and decreased memory. There are no conclusive diagnostic tests for CFS.  Since the underlying mechanism for CFS is not known, finding reliable biomarkers for diagnosing are important. 

The purpose of this study was to examine the use of serum nicotinamide adenine dinucleotide (NAD(P)H) levels as a metabolic marker of fatigue state and alterations in metabolism and homeostasis in CFS patients. 

The Riordan Clinic scientists have developed a method of determining NAD(P)H levels based on fluorescence emission of serum at 450 nm. Serum NAD(P)H concentrations were  compared for subjects with CFS and healthy controls.  NAD(P)H concentrations in the serum of CFS subjects averaged 8.0 +/- 1.4 (SD) uM while those in healthy controls averaged 10.8 +/- 0.8 (SD) uM, a statistically significant difference (p < 0.001). 

The sensitivity (detection of positives) and specificity (non-detection of negatives) of the test in matching CFS patients to control subjects at NAD(P)H cut-off of 9.5 uM were 0.73 and 0.98.   

The researchers also compared NAD(P)H concentrations to other endocrine and metabolic parameters. A factor
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