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Rigel to Present Research Programs at Scientific Conferences
Date:10/16/2007

SOUTH SAN FRANCISCO, Calif., Oct. 16 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that its scientists will be presenting three poster presentations at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco, October 22-26, 2007. They will highlight drug discovery efforts focused on significant cancer targets including Axl receptor tyrosine kinase (Axl), Polo- like kinase 1 (PLK1) and Janus tyrosine kinase 2 (JAK2).

Axl kinase is a novel therapeutic target for solid tumors. Signaling via Axl drives proliferation, migration and invasion of tumor cells. The data to be presented shows that Axl inhibition may suppress tumor growth via multiple mechanisms. Rigel has potent, small molecule, orally bioavailable Axl inhibitors that show activity in reducing tumor growth and invasion in animal models. One of Rigel's collaborators will also present on Axl at the AACR Special Conference on Advances in Breast Cancer Research in San Diego, October 17-20, 2007.

Selective inhibition of PLK1 could be important in cancer treatment. Rigel has discovered a new class of small molecule PLK1 inhibitors using its image-based high content screening capabilities, which were previously used to discover an Aurora Kinase inhibitor that is currently in clinical studies as a potential cancer therapeutic.

Rigel's scientific team will also be presenting a poster at the International Cytokine Society meeting, October 26-30, 2007 in San Francisco, California.

Poster Presentation at AACR's Advances in Breast Cancer Research

Wednesday, October 17th, 8:00-10:00pm

The receptor tyrosine kinase Axl regulates breast carcinoma cell

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SOURCE Rigel Pharmaceuticals, Inc.
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