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RiboMed Receives Three Additional Patents for Disease Diagnostics Methods
Date:12/5/2012

0&s1=8,242,243.PN.&OS=PN/8,242,243&RS=PN/8,242,243" title="Patent 2" onclick="linkClick(this.href)">“Methods and reagents for detecting CpG methylation with a methyl CpG binding protein (MBP)” covers a highly quantitative and sensitive, bisulfite-free method for measuring DNA methylation at CpG sites and CpG islands using RiboMed’s proprietary Methyl CpG binding fusion protein. This work was supported in part by Small Business Innovative Research grant and contract awards from the National Cancer Institute. In addition to the currently available brain cancer staging test, RiboMed is developing similar DNA methylation profile based diagnostic, prognostic and companion diagnostic tests for ovarian and lung cancers.

Finally, U.S. Patent 8,211,644, entitled “Molecular beacon based methods for detection of targets using Abscription” provides claims to sensitive fluorescence-based methods using molecular beacons to detect the products of Abscription and makes real time detection methods possible. The molecular beacon-based technology makes Abscription more attractive to the vast majority of clinical and research laboratories that do not have access to a mass spectrometer, which is used for the current G-CIMP assay, but routinely use fluorescence detection instruments. The molecular beacon format allows for more streamlined workflows and faster assay set-up. The new fluorescence read-out is readily adapted for the detection of RNA, DNA and protein targets and should have wide applicability in areas such as cancer diagnostics and environmental testing.

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