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Rib-X Pharmaceuticals to Present at the 49th ICAAC

NEW HAVEN, Conn., Sept. 10 /PRNewswire/ -- Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a development-stage company focused on the discovery, development and commercialization of novel antibiotics for the treatment of acute care antibiotic-resistant infections, today announced that seven posters have been accepted for presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) taking place in San Francisco, CA on September 12-15, 2009. Details on these presentations are as follows:

    Date      Time      Session         Title                    Presentation

    Sept. 13  11:15am-  Oxazolidinones  In Vitro Activity of     Hall B
              1:15pm                    Radezolid against MRSA   Poster #277
                                        Causing Skin and Wound   Present-
                                        Infections from the      ation
                                        United States, Europe,   #E-810
                                        and Asia

    Sept. 13  11:15am-  New Research    Novel Antibiotic Classes Hall B
              1:15pm    Technologies    to Treat Gram-Negative   Poster #332
                        and             Infections               Present-
                        Methodologies                            ation

    Sept. 14  11:15am-  Antibiotic      Anti-MRSA Properties of  Hall B
              1:15pm    Resistance in   Delafloxacin: Mutant     Poster #101
                        Staphylococcus  Analysis and             Present-
                        aureus          Characterization         ation

    Sept. 15  9:00am-   PK/PD           Clinical Trial Dose      Hall D
              11:00am   Investigational Selection for            Poster #15
                        Antibacterials  Delafloxacin (DFX) for   Present-
                                        Complicated Skin and     ation
                                        Skin-Structure           #A1-1942
                                        Infections (cSSSI)

    Sept. 15  9:00am-   New Macrolides  Enhanced Macrolides:     Hall D
              11:00am   and Ketolides   Optimized Molecular      Poster #125
                                        Properties for Oral      Present-
                                        Exposure                 ation

    Sept. 15  9:00am-   New Macrolides  Enhanced Macrolides:     Hall D
              10:00am   and Ketolides   Overcoming Resistance    Poster #126
                                        by Improving Target      Present-
                                        Affinity                 ation

    Sept. 15  9:00am-   PK/PD           Pharmacokinetics and     Hall D
              11:00am   Investigational Pharmacodynamics of      Poster #14
                        Antibacterials  Delafloxacin in S.       Present-
                                        aureus Murine Thigh      ation
                                        Infection Models         #A1-1941

"It is very satisfying to present for critical review the scientific developments Rib-X has fostered during the past year and in four distinctive antibiotic programs. It is especially rewarding to receive input from our peers at the premier anti-infective conference," said Susan Froshauer, PhD, President and Chief Executive Officer, Rib-X Pharmaceuticals. "We are particularly pleased to present proof-of-concept data on our novel chemical class Gram-negative program."

About Rib-X Pharmaceuticals, Inc.

Rib-X Pharmaceuticals, Inc. is a product-driven small molecule drug discovery and development company focused on the structure-based design of new classes of antibiotics. The Company's underlying drug discovery engine capitalizes on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role in protein synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ribosome. The Company's integrated research strategy, which combines state-of-the-art, proprietary computational analysis, X-ray crystallography, medicinal chemistry, microbiology and biochemistry, allows it to rapidly synthesize new agents designed to avoid typical antibiotic resistance mechanisms. Rib-X's iterative intelligent engine has yielded several distinctive new antibiotics that can be used for the treatment of either community- or hospital-acquired infections. In addition to Rx-04, Rib-X has successfully completed Phase 2 trials with delafloxacin (RX-3341), a broad spectrum fluoroquinolone with potent activity against quinolone resistant Gram-positive bacteria including MRSA. Radezolid (RX-1741), an oxazolidinone that was discovered at Rib-X, as an oral/IV agent for treatment of serious Gram-positive infections has completed two Phase 2 trials and the Rx-02 discovery program which is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus, multidrug-resistant Streptococcus pneumoniae and S. pyogenes. Both delafloxacin and radezolid are currently in late stage clinical trials.

For more information on the Rib-X mission and the pipeline, please visit the Company website at

For further information please contact:

    Irma Gomez-Dib
    FD Life Sciences
    Tel: 212-850-5761

    John Capodanno
    FD Life Sciences
    Tel: 212-850-5705

SOURCE Rib-X Pharmaceuticals, Inc.
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All rights reserved

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