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Rib-X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram-negative Bacteria
Date:8/31/2009

that are active against Gram-negative bacteria. This program exploits the peptidyl transferase region of the 50S subunit, which is the catalytic region of the ribosome and the binding site of many chemically distinct classes of antibiotics, including oxazolidinones (e.g., linezolid), lincosamides (e.g., clindamycin), phenyl propanoids (e.g., chloramphenicol), pleuromutilins (e.g., retapamulin), macrolides/ketolides (e.g., azithromycin) and sparsomycin. Rib-X has created five completely novel series of compounds targeting two novel sites that show good antibacterial activity against a number of clinically important multi drug resistant Gram-negative pathogens.

About Rib-X Pharmaceuticals, Inc.

Rib-X Pharmaceuticals, Inc. is a product-driven small molecule drug discovery and development company focused on the structure-based design of new classes of antibiotics. The Company's underlying drug discovery engine capitalizes on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role in protein synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ribosome. The Company's integrated research strategy, which combines state-of-the-art, proprietary computational analysis, X-ray crystallography, medicinal chemistry, microbiology and biochemistry, allows it to rapidly synthesize new agents designed to avoid typical antibiotic resistance mechanisms. Rib-X's iterative intelligent engine has yielded several distinctive new antibiotics that can be used for the treatment of either community- or hospital-acquired infections. In addition to Rx-04, Rib-X has successfully completed Phase 2 trials with delafloxacin (RX-3341), a broad spectrum fluoroquinolone with potent activity against quinolone resistant Gram-positive bacteria including MRSA. Radezolid (RX-1741), an oxazolidinone that was discovered at Rib-X, as an oral/IV agent for treatment of ser
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