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Rib-X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram-negative Bacteria
Date:8/31/2009

NEW HAVEN, Conn., Aug. 31 /PRNewswire/ -- Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a development-stage company focused on the discovery, development and commercialization of novel antibiotics for the treatment of acute care antibiotic-resistant infections, today announced that one of its discovery-stage programs has yielded several computationally designed series of chemically unique compounds demonstrating efficacy in the treatment of infection in animal models.

The Rx-04 discovery program is focused on the development of novel classes of antibiotics active against serious, rapidly emerging multi-drug resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. The company has built five chemical scaffolds, some of which have demonstrated activity against both Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Data from an earlier, related program will be presented during a poster sessions at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco.

"In less than one year, our structure and computationally driven research engine has engineered a variety of new lead scaffolds that appear to exhibit promising activity in mice, good drug-like properties and good safety in early tests, in addition to varied profiles against MDR gram-negative pathogens in vitro," said Susan Froshauer, PhD, President and CEO of Rib-X Pharmaceuticals. "The success we've seen to date with our later clinical stage antibiotic compounds, radezolid and delafloxacin, along with the immense progress made on the Rx-04 program, underscores the strength and diversity of the growing Rib-X pipeline."

About Rx-04

The Rx-04 program employs a de novo approach to develop novel antibiotics
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SOURCE Rib-X Pharmaceuticals, Inc.
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