Novel Fluoroquinolone Demonstrates Safety and Efficacy in Treatment of Skin Infections
NEW HAVEN, Conn., Jan. 26 /PRNewswire/ -- Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a development-stage company focused on the discovery and development of novel antibiotics for the treatment of antibiotic-resistant infections, today announced positive final results from a Phase 2 clinical trial of its novel fluoroquinolone antibiotic, delafloxacin (RX-3341), in the treatment of complicated skin and skin structure infections (cSSSI).
Separately, Rib-X today also announced that the company closed on a $25 million financing, which will fund the ongoing development of its pipeline of novel antibiotics. This round included participation from all of Rib-X's major investors, including: Warburg Pincus, ABS Ventures, Axiom Ventures, EuclidSR Partners, MedImmune Ventures, Oxford Bioscience Partners, S.R. One, and Vox Equity Partners I.
In the double-blind study, delafloxacin was administered intravenously at two different doses, 300 mg twice daily (BID) and 450 mg BID; the comparator was tigecycline (TYGACIL(R), Wyeth Pharmaceuticals), the only broad spectrum agent recently approved (2005) by the FDA for use in cSSSI. Delafloxacin showed comparable efficacy and improved tolerability relative to tigecycline at the FDA-approved dosing regimen for this indication. In the clinically evaluable population, the cure rates for delafloxacin 300 mg BID and 450 mg BID were 97.2% and 92.5%, respectively, while the cure rate for tigecycline was 91.2%.
Staphylococcus aureus was the most frequently isolated pathogen, accounting for approximately 85% of all pathogens collected. Approximately 70% (68/96) of the S. aureus isolates were methicillin-resistant (MRSA) and 63% of the MRSA were levofloxacin resistant. MIC90 values for delafloxacin, tigecycline, and levofloxacin against all S. aureus'/>"/>
|SOURCE Rib-X Pharmaceuticals, Inc.|
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