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Rhythm's RM-131 Restores GI Function as a Potent Ghrelin Prokinetic
Date:5/9/2011

the U.S. and causes chronic nausea, vomiting, malnutrition, and a high rate of hospitalization. The U.S. economic cost of gastroparesis is estimated to total $3.5 billion, and annual hospitalization costs for diabetic gastroparesis exceed $200 million.

About RM-131

RM-131 is a small-peptide analog of ghrelin, a hormone produced in the stomach that stimulates gastrointestinal activity, mitigates proinflammatory cytokine production, and is the only hormone known to stimulate appetite. Derived from the natural ghrelin sequence, RM-131 has been optimized to stimulate gastrointestinal motility and anti-inflammatory activity, with enhanced stability and pharmacokinetics.

About Rhythm (www.rhythmtx.com)

Rhythm is a biotechnology company developing peptide therapeutics that address unmet needs in metabolic diseases. Rhythm investors include MPM Capital, New Enterprise Associates, and Third Rock Ventures. The company is based in Boston, Massachusetts.

Contact:
Bart Henderson
President
(617) 425-9219
bhenderson@rhythmtx.com


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