Navigation Links
Rhythm's RM-131 Restores GI Function as a Potent Ghrelin Prokinetic
Date:5/9/2011

BOSTON, May 9, 2011 /PRNewswire/ -- Rhythm announced today results demonstrating that RM-131, the company's novel ghrelin agonist, was highly effective in restoring normal gastric function in animal models of delayed gastric emptying owing to a direct prokinetic effect. The results were the subject of an oral presentation by Lee M. Kaplan, MD, PhD (Massachusetts General Hospital, Harvard Medical School) titled "RM-131: A Potent Gastroprokinetic Agent" at the Digestive Disease Week 2011 conference in Chicago on Saturday, May 7, 2011.

"This study suggests RM-131's significant inherent potential for the treatment of common GI functional disorders such as diabetic gastroparesis," said Elizabeth Stoner, MD, Chief Development Officer of Rhythm. "Diabetic patients with gastroparesis experience high rates of hospitalization due to vomiting and nausea, and their ability to maintain glucose is significantly challenged by their inability to eat normally. We are developing RM-131 to improve outcomes for these types of GI disorders."

In this in vivo study, RM-131 fully restored gastric emptying in a progressive, dose-dependent manner and demonstrated 100 times greater potency compared with natural human ghrelin. In addition, RM-131 was shown to be more effective in restoring GI function compared with GHSR agonists such as ipamorelin. The study was performed by scientists at Ipsen who discovered RM-131.

"The results from this head-to-head testing are compelling and demonstrate RM-131's potential to restore impaired GI function," said Bart Henderson, President of Rhythm. "The diabetes epidemic is driving a significant increase in patients with gastroparesis, but patients today have very limited treatment options. RM-131 is now in Phase 1 human clinical trials to assess its potential for treating gastroparesis and other important functional GI disorders."

About Gastroparesis

Gastroparesis affects up to 30% of the 24 million diabetics in the U.S. and causes chronic nausea, vomiting, malnutrition, and a high rate of hospitalization. The U.S. economic cost of gastroparesis is estimated to total $3.5 billion, and annual hospitalization costs for diabetic gastroparesis exceed $200 million.

About RM-131

RM-131 is a small-peptide analog of ghrelin, a hormone produced in the stomach that stimulates gastrointestinal activity, mitigates proinflammatory cytokine production, and is the only hormone known to stimulate appetite. Derived from the natural ghrelin sequence, RM-131 has been optimized to stimulate gastrointestinal motility and anti-inflammatory activity, with enhanced stability and pharmacokinetics.

About Rhythm (www.rhythmtx.com)

Rhythm is a biotechnology company developing peptide therapeutics that address unmet needs in metabolic diseases. Rhythm investors include MPM Capital, New Enterprise Associates, and Third Rock Ventures. The company is based in Boston, Massachusetts.

Contact:
Bart Henderson
President
(617) 425-9219
bhenderson@rhythmtx.com


'/>"/>
SOURCE Rhythm
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. U.S. Hospital Sales Opportunities Maximized Through Functional Optimization
2. Golimumab Phase 3 Data Show Significant Improvement In Physical Function In Patients with Rheumatoid Arthritis
3. Premier Research Achieves Double-Digit Growth in Functional Sourcing for the Third Straight Year
4. RVX-208 Data Demonstrates Increase in Functional HDL Particles
5. CorMatrix Announces Pre-Clinical Data Suggesting Next Generation ECM Technology(TM) Can Improve Cardiac Function
6. Kidneys for Transplant Function Earlier and Last Longer When Preserved in a Machine Compared to the Traditional Box of Ice
7. Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling
8. NeuroFocus Names John Polich, World-Renowned Scientist in Brain Function and Cognition, to Head Global NeuroLab Operations
9. GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools
10. Kibow Biotech Strongly Supports World Kidney Day for Maintenance of Healthy Kidney Function
11. Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... Ginkgo Bioworks, the organism company, announced ... the synthesis and assembly of DNA. The acquisition ... synthetic DNA into Ginkgo,s automated organism engineering foundries, ... of new organism designs for application across a ... founded to significantly increase the world,s capacity to ...
(Date:1/19/2017)... HOUSTON , Jan. 19, 2017 ... announced the formation of its Medical/Clinical Advisory Board. ... industry veterans who enhance the range and depth ... development of its novel prenatal diagnostic tests.  These ... and strategic guidance for the company,s product development ...
(Date:1/19/2017)... Md. and GAITHERSBURG, Md. ... (NYSE MKT: PIP) and Altimmune, Inc., a privately-held ... signing of a definitive agreement for the merger ... Altimmune,s current investors include Novartis Venture Fund, HealthCap, ... will be a fully-integrated and diversified immunotherapeutics company ...
(Date:1/19/2017)... Staten Island, NY (PRWEB) , ... January 19, 2017 , ... ... expand at an exponential rate. The tremendous growth is accounted to two main ... to the table and the expanding network of vendors supplying FireflySci products all around ...
Breaking Biology Technology:
(Date:1/11/2017)... N.J. , Jan. 11, 2017  Michael Johnson, co-founder of ... Venture Capital Group, Inc., has been named to the elite "Forbes ... 27,  was one of 600 people in 20 fields nationwide to ... percent of the 15,000 applicants were selected. ... He is currently a PhD candidate at ...
(Date:1/6/2017)... , Jan. 5, 2017  Delta ID Inc., ... iris scanning technology for automotive at CESĀ® 2017. Delta ... GNTX ) to demonstrate the use of iris scanning ... and authenticate the driver in a car, and as ... the driving experience. Delta ID and Gentex ...
(Date:1/3/2017)... 3, 2017 Onitor, provider of digital health ... Track, an innovative biometric data-driven program designed to aid ... at the 2017 Consumer Electronics Show (CES) in ... the U.S., the World Health Organization (WHO), have identified ... adults who are overweight or obese. WHO also states ...
Breaking Biology News(10 mins):